Evidence map›Paper›PMID 30777641›Full record

ReviewTrends in cognitive sciences2019

Exercise and Hippocampal Memory Systems.

Michelle W Voss, Carmen Soto, Seungwoo Yoo, Matthew Sodoma, Carmen Vivar, Henriette van Praag

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cognitive sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 144 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
144citing papers in PubMed, 6 pooled it
11.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

144 citing papers in PubMed, 6 syntheses or guidelines pooled it, 234 citations in OpenAlex.

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84 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Michelle W VossDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA. Electronic address: michelle-voss@uiowa.edu.
Carmen SotoLaboratory of Neurogenesis and Neuroplasticity, Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico.
Seungwoo YooDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA.
Matthew SodomaDepartment of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA.
Carmen VivarLaboratory of Neurogenesis and Neuroplasticity, Department of Physiology, Biophysics and Neuroscience, Center for Research and Advanced Studies of the National Polytechnic Institute, Mexico City, Mexico.
Henriette van PraagDepartment of Biomedical Science, Charles E. Schmidt College of Medicine, and Brain Institute, Florida Atlantic University, Jupiter, FL 33458, USA.
Florida Atlantic University · USUniversity of Iowa · USInstituto Politécnico Nacional · MXTecnológico Nacional de México · MX

Funding

Exercise to improve hippocampal connectivity and learning in older adultsR01AG055500 · NIA · UNIVERSITY OF IOWA · PI VOSS, MICHELLE WEBB · 2017 to 2021
$3.5M
Mechanisms of Health and Disease at the Behavioral-Biomedical InterfaceT32GM108540 · NIGMS · UNIVERSITY OF IOWA · PI LUTGENDORF, SUSAN K, VOSS, MICHELLE WEBB · 2014 to 2023
$1.7M
NIA NIH HHS R01 AG055500NIGMS NIH HHS T32 GM108540
6 · The paper itself

Abstract

No medications prevent or reverse age-related cognitive decline. Physical activity (PA) enhances memory in rodents, but findings are mixed in human studies. As a result, exercise guidelines specific for brain health are absent. Here, we re-examine results from human studies, and suggest the use of more sensitive tasks to evaluate PA effects on age-related changes in the hippocampus, such as relational memory and mnemonic discrimination. We discuss recent advances from rodent and human studies into the underlying mechanisms at both the central and peripheral levels, including neurotrophins and myokines that could contribute to improved memory. Finally, we suggest guidelines for future research to help expedite well-founded PA recommendations for the public.

Indexed as

AgingAnimalsExerciseHippocampusHumansMemoryaginggrowth factorshippocampusmyokinesneurogenesispattern separationphysical activityrelational memory

Identifiers

PMID30777641
PMCPMC6422697
OpenAlexW2913278175

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.