Observational studyAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2019
Fasting Urinary Osmolality, CKD Progression, and Mortality: A Prospective Observational Study.
Observational study in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 35 citations in OpenAlex.
- Association between kidney function and risk of hyponatremia: a single-center, cross-sectional study in the outpatient setting.Clinical and experimental nephrology · 2026Article
- Beneficial effect of sodium-glucose cotransporter 2 inhibitors on kidney function can be just a mirage.World journal of nephrology · 2025Review
- Understanding Renal Tubular Function: Key Mechanisms, Clinical Relevance, and Comprehensive Urine Assessment.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Review
- Is mild dehydration a risk for progression of childhood chronic kidney disease?Pediatric nephrology (Berlin, Germany) · 2024Review
- Redefining the concept of residual renal function with kidney sodium MRI: a pilot study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024Observational
- Low daily water intake profile-is it a contributor to disease?Nutrition and health · 2024Review
- Alteration of the maximal renal water excretion capacity with kidney function and age in human.International urology and nephrology · 2024Article
- Water intake, baseline biopsy, and graft function after living donor kidney transplantation.Scientific reports · 2024Article
- Evaluating the Effects of Kidney Preservation at 10 °C with Hemopure and Sodium Thiosulfate in a Rat Model of Syngeneic Orthotopic Kidney Transplantation.International journal of molecular sciences · 2024Article
- Hospital admissions associated with dehydration in childhood kidney transplantation.Pediatric nephrology (Berlin, Germany) · 2024Article
- Urine concentration impairment in sickle cell anemia: genuine nephrogenic diabetes insipidus or osmotic diuresis?American journal of physiology. Renal physiology · 2024Observational
- Urine-to-plasma creatinine ratio and fractional excretion of urea performance in acute-on-chronic kidney disease patients.Journal of nephrology · 2023Article
- Recent Advances in Sodium Magnetic Resonance Imaging and Its Future Role in Kidney Disease.Journal of clinical medicine · 2023Review
- Mechanistic insights into the primary and secondary alterations of renal ion and water transport in the distal nephron.Journal of internal medicine · 2023Review
- Prognostic impact of urine cyclic AMP levels in patients with chronic kidney disease.Clinical and experimental nephrology · 2022Article
- Chronic Lithium Therapy and Urine-Concentrating Ability in Individuals With Bipolar Disorder: Association Between Daily Dose and Resistance to Vasopressin and Polyuria.Kidney international reports · 2022Article
- The association of urine osmolality with decreased kidney function and/or albuminuria in the United States.BMC nephrology · 2021Article
- Cerebral Ultrasound Time-Harmonic Elastography Reveals Softening of the Human Brain Due to Dehydration.Frontiers in physiology · 2020Article
Corrections and comments
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Authors and funding
11 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RATIONALE &
objectiveChronic kidney disease (CKD) characterized by decreased glomerular filtration rate (GFR) is often accompanied by various degrees of impaired tubular function in the cortex and medulla. Assessment of tubular function may therefore be useful in establishing the severity of kidney disease and identifying those at greater risk for CKD progression. We explored reductions in urinary concentrating ability, a well-known feature of CKD, as a risk factor for GFR decline and end-stage renal disease (ESRD). STUDY
designProspective longitudinal cohort study. SETTING &
participants2,084 adult patients with CKD stages 1 to 4 from the French NephroTest Cohort Study. PREDICTOR: Fasting urinary osmolality measured using delta cryoscopy. OUTCOMES: ESRD, mortality before ESRD, and measured GFR (mGFR) assessed using ANALYTICAL APPROACH: Cause-specific hazards models were fit to estimate crude and adjusted associations of urinary osmolality with ESRD and death before ESRD. Linear mixed models with random intercepts were fit to evaluate the association of urinary osmolality with slope of decline in mGFR.
resultsAt baseline, mean age was 58.7±15.2 (SD) years with a median mGFR of 40.2 (IQR, 29.1-54.5) mL/min/1.73m LIMITATIONS: Fasting was self-reported.
conclusionsFasting urinary osmolality may be a useful tool, in addition to GFR and albuminuria, for assessing nonglomerular damage in patients with CKD who are at higher risk for CKD progression.
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