ArticleBiological psychiatry. Cognitive neuroscience and neuroimaging2019
Functional Connectivity of Frontoparietal and Salience/Ventral Attention Networks Have Independent Associations With Co-occurring Attention-Deficit/Hyperactivity Disorder Symptoms in Children With Autism.
Article in Biological psychiatry. Cognitive neuroscience and neuroimaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 50 citations in OpenAlex.
- Attention and learning strategies reveal distinct dimensions of psychiatric diseases.Research square · 2026Article
- Contribution of attentional mechanisms to verbal and nonverbal communication in boys with ASD.European child & adolescent psychiatry · 2026Article
- Altered Temporospatial Variability of Dynamic Amplitude of Low-Frequency Fluctuation in Children with Autism Spectrum Disorder.Journal of autism and developmental disorders · 2026Article
- Integrating Multimodal Neuroimaging and Physical-Health Markers for Autism Spectrum Disorder in the ABCD Study.Journal of integrative neuroscience · 2026Article
- Article
- Functional connectivity patterns differ as a function of co-occurring attentional problems in preschoolers with autism.Journal of neurodevelopmental disorders · 2025Article
- Cross-Sectional Mega-Analysis of Resting-State Alterations Associated with Autism and Attention-Deficit/Hyperactivity Disorder in Children and Adolescents.Nature. Mental health · 2025Article
- Blurred magnitude homology of functional connectome for ASD diagnosis.Frontiers in psychiatry · 2025Article
- Ventral Attention Network Resting State Functional Connectivity: Psychosocial Correlates among US Adolescents.Journal of biomedical and life sciences · 2025Article
- Where do neurodevelopmental conditions fit in transdiagnostic psychiatric frameworks? Incorporating a new neurodevelopmental spectrum.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2024Article
- Spatial-Temporal Characteristics of Brain Activity in Autism Spectrum Disorder Based on Hidden Markov Model and Dynamic Graph Theory: A Resting-State fMRI Study.Brain sciences · 2024Article
- Intrinsic network abnormalities in children with autism spectrum disorder: an independent component analysis.Brain imaging and behavior · 2024Article
- Delineating Transdiagnostic Subtypes in Neurodevelopmental Disorders via Contrastive Graph Machine Learning of Brain Connectivity Patterns.bioRxiv : the preprint server for biology · 2024Article
- Personalized functional network mapping for autism spectrum disorder and attention-deficit/hyperactivity disorder.Translational psychiatry · 2024Article
- Heterogeneity and convergence across seven neuroimaging modalities: a review of the autism spectrum disorder literature.Frontiers in psychiatry · 2024Review
- Distinct Frontoparietal Brain Dynamics Underlying the Co-Occurrence of Autism and ADHD.eNeuro · 2023Article
- Group linear non-Gaussian component analysis with applications to neuroimaging.Computational statistics & data analysis · 2022Article
- More than the sum of its parts: Merging network psychometrics and network neuroscience with application in autism.Network neuroscience (Cambridge, Mass.) · 2022Article
- Utility of Cognitive Neural Features for Predicting Mental Health Behaviors.Sensors (Basel, Switzerland) · 2022Article
- Altered single-subject gray matter structural networks in drug-naïve attention deficit hyperactivity disorder children.Human brain mapping · 2022Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundChildren with autism spectrum disorder (ASD) and co-occurring attention-deficit/hyperactivity disorder (ADHD) symptoms have worse functional outcomes and treatment response than those without ADHD symptoms. There is limited knowledge of the neurobiology of ADHD symptoms in ASD. Here, we test the hypothesis that aberrant functional connectivity of two large-scale executive brain networks implicated in ADHD-the frontoparietal and salience/ventral attention networks-also play a role in ADHD symptoms in ASD.
methodsWe compared resting-state functional connectivity of the two executive brain networks in children with ASD (n = 77) and typically developing control children (n = 82). These two executive brain networks comprise five subnetworks (three frontoparietal, two salience/ventral attention). After identifying aberrant functional connections among subnetworks, we examined dimensional associations with parent-reported ADHD symptoms.
resultsWeaker functional connectivity in ASD was present within and between the frontoparietal and salience/ventral attention subnetworks. Decreased functional connectivity within a single salience/ventral attention subnetwork, as well as between two frontoparietal subnetworks, significantly correlated with ADHD symptoms. Furthermore, follow-up linear regressions demonstrated that the salience/ventral attention and frontoparietal subnetworks explain unique variance in ADHD symptoms. These executive brain network-ADHD symptom relationships remained significant after controlling for ASD symptoms. Finally, specificity was also demonstrated through the use of a control brain network (visual) and a control co-occurring symptom domain (anxiety).
conclusionsThe present findings provide novel evidence that both frontoparietal and salience/ventral attention networks' weaker connectivities are linked to ADHD symptoms in ASD. Moreover, co-occurring ADHD in the context of ASD is a source of meaningful neural heterogeneity in ASD.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.