Evidence map›Paper›PMID 30777379›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2019

Hospitalization, surgery, and incident dementia.

Lars I Eriksson, Cecilia Lundholm, Kaavya Narasimhalu, Rolf Sandin, Ya-Ping Jin, Margaret Gatz, Nancy L Pedersen

Open access · greenAbstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2020
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Lars I ErikssonDepartment of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden; Function Perioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden.
Cecilia LundholmDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Kaavya NarasimhaluDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Rolf SandinDepartment of Physiology and Pharmacology, Section for Anesthesiology and Intensive Care Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Anesthesia and Intensive Care, Kalmar County Hospital, Kalmar, Sweden.
Ya-Ping JinDepartment of Ophthalmology and Vision Sciences, Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada.
Margaret GatzDepartment of Psychology, University of Southern California, Los Angeles, CA, USA; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Psychology, University of Southern California, Los Angeles, CA, USA. Electronic address: nancy.pedersen@ki.se.
Karolinska Institutet · SEKarolinska University Hospital · SELandstinget i Kalmar län · SEUniversity of Toronto · CA

Funding

Clarifying risk and protective factors for dementia with the Interplay of Genes and Environment in Multiple Studies (IGEMS) consortiumR01AG060470 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET, PEDERSEN, NANCY L · 2018 to 2022
$3.6M
DEMENTIA IN TWINSR01AG008724 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GATZ, MARGARET · 1990 to 2002
$1.4M
NIA NIH HHS R01 AG008724NIA NIH HHS R01 AG060470
6 · The paper itself

Abstract

introductionWe evaluated whether hospitalization with or without surgery increases risk for dementia or Alzheimer's disease.

methodsA clinical sample (843 clinically diagnosed dementia cases; 1686 matched nondemented individuals) was identified from Swedish Twin Registry studies. A register-based sample (4293 cases; 21,465 matched controls) was identified by linkage of Swedish Twin Registry to Swedish Patient Registry records. Apolipoprotein E (APOE) status and within-pair comparisons of dementia discordant twins indicated genetic susceptibility.

resultsNonsurgical hospitalization is associated with greater dementia risk than hospitalization with surgical intervention. In the register sample, thoracic, abdominal, and major orthopedic procedures entailed dementia risk; in the clinical sample, orthopedic alone. Within-pair analyses indicate that associations in part reflect genetic susceptibility in common to hospitalization and dementia. Potential gene-environment interactions were indicated by greater risk due to hospitalization among APOE ε4 noncarriers. DISCUSSION: We confirm hospitalization as a risk factor for dementia, with repeated hospitalizations a more important risk factor than surgery.

Indexed as

HospitalizationAgedAged, 80 and overApolipoproteins ECase-Control StudiesDementiaElective Surgical ProceduresFemaleGenetic Predisposition to DiseaseGenotypeHumansMaleMiddle AgedRegistriesRisk FactorsSwedenApolipoproteins EAlzheimer's diseaseAPOECo-twin controlDementiaHospitalizationNested case-controlSurgery

Identifiers

PMID30777379
PMCPMC6461518
OpenAlexW2911899955

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.