ArticleBiophysical journal2019
Lipid Unsaturation Properties Govern the Sensitivity of Membranes to Photoinduced Oxidative Stress.
Article in Biophysical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Degradation, Osmosis and the Emergence of Basic Functionalities in Abiotic Synthetic Life-like Chemical Systems.Life (Basel, Switzerland) · 2026Article
- Membrane stability under heat stress: molecular signaling, lipid remodeling, and defense mechanisms in plants.Plant cell reports · 2026Review
- Antimicrobial peptide-targeted photodynamic therapy for preventing periodontal plaque biofilm formation through the disruption of quorum sensing system.Materials today. Bio · 2025Article
- Photoswitchable Molecular Motor Phospholipid: Synthesis, Characterization, and Integration into Lipid Vesicles.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- PGC-1Acta pharmaceutica Sinica. B · 2024Article
- Curvature-Assisted Vesicle Explosion Under Light-Induced Asymmetric Oxidation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Evaluation of the Protective Role of Vitamin E against ROS-Driven Lipid Oxidation in Model Cell Membranes.Antioxidants (Basel, Switzerland) · 2024Article
- Bioprinting of Synthetic Cell-like Lipid Vesicles to Augment the Functionality of Tissues after Manufacturing.ACS synthetic biology · 2024Article
- NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis.The EMBO journal · 2024Article
- Two separate mechanisms are involved in membrane permeabilization during lipid oxidation.Biophysical journal · 2023Article
- Review of Lipid Biomarkers and Signals of Photooxidative Stress in Plants.Methods in molecular biology (Clifton, N.J.) · 2023Review
- Dynamics of mitochondrial membranes under photo-oxidative stress with high spatiotemporal resolution.Frontiers in cell and developmental biology · 2023Article
- Structure-activity relationships of mitochondria-targeted tetrapeptide pharmacological compounds.eLife · 2022Article
- Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases.Nature communications · 2022Article
- Imaging of Lipid Peroxidation-Associated Chemiluminescence in Plants: Spectral Features, Regulation and Origin of the Signal in Leaves and Roots.Antioxidants (Basel, Switzerland) · 2022Article
- Elucidation of the Interactions of Reactive Oxygen Species and Antioxidants in Model Membranes Mimicking Cancer Cells and Normal Cells.Membranes · 2022Article
- Article
- Light-Triggered Cargo Loading and Division of DNA-Containing Giant Unilamellar Lipid Vesicles.Nano letters · 2021Article
- Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles.Nature protocols · 2021Review
- Photochemically induced cyclic morphological dynamics via degradation of autonomously produced, self-assembled polymer vesicles.Communications chemistry · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unsaturated lipid oxidation is a fundamental process involved in different aspects of cellular bioenergetics; dysregulation of lipid oxidation is often associated with cell aging and death. To study how lipid oxidation affects membrane biophysics, we used a chlorin photosensitizer to oxidize vesicles of various lipid compositions and degrees of unsaturation in a controlled manner. We observed different shape transitions that can be interpreted as an increase in the area of the targeted membrane followed by a decrease. These area modifications induced by the chemical modification of the membrane upon oxidation were followed in situ by Raman tweezers microspectroscopy. We found that the membrane area increase corresponds to the lipids' peroxidation and is initiated by the delocalization of the targeted double bonds in the tails of the lipids. The subsequent decrease of membrane area can be explained by the formation of cleaved secondary products. As a result of these area changes, we observe vesicle permeabilization after a time lag that is characterized in relation with the level of unsaturation. The evolution of photosensitized vesicle radius was measured and yields an estimation of the mechanical changes of the membrane over oxidation time. The membrane is both weakened and permeabilized by the oxidation. Interestingly, the effect of unsaturation level on the dynamics of vesicles undergoing photooxidation is not trivial and thus carefully discussed. Our findings shed light on the fundamental dynamic mechanisms underlying the oxidation of lipid membranes and highlight the role of unsaturations on their physical and chemical properties.
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