Evidence map›Paper›PMID 30777118›Full record

Trial reportTrials2019

Impact of two oral doses of 100,000 IU of vitamin D

Francine Monique Ducharme, Megan Jensen, Geneviève Mailhot, Nathalie Alos, John White, Elizabeth Rousseau, Sze Man Tse, Ali Khamessan, Benjamin Vinet

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02197702 (Vitamin D In the Prevention of Viral-induced Asthma of Preschoolers), which is not on this map. Cited by 19 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 6 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02197702 phase2 / phase3completednot on this map

Vitamin D In the Prevention of Viral-induced Asthma of Preschoolers: a Randomised Controlled Trial (RCT)- (DIVA)

TypeinterventionalSponsorSt. Justine's HospitalRan2014 to 2016Enrolled47ConditionsAsthmaArmsvitamin D, placebo
3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 6 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Francine Monique DucharmeClinical Research and Knowledge Transfer Unit on Childhood Asthma, Research Centre, Sainte-Justine University Health Centre, Montreal, Quebec, Canada. francine.m.ducharme@umontreal.ca.ORCID http://orcid.org/0000-0001-5096-0614
Megan JensenClinical Research and Knowledge Transfer Unit on Childhood Asthma, Research Centre, Sainte-Justine University Health Centre, Montreal, Quebec, Canada.
Geneviève MailhotDepartment of Nutrition, University of Montreal, Montreal, Quebec, Canada.
Nathalie AlosDepartment of Social and Preventive Medicine, University of Montreal, Montreal, Quebec, Canada.
John WhiteDepartment of Physiology, McGill University, Montreal, Quebec, Canada.
Elizabeth RousseauDepartment of Pediatrics, University of Montreal, Sainte-Justine University Health Centre, 3175 Côte Ste-Catherine, Montreal, Quebec, H3T 1C5, Canada.
Sze Man TseClinical Research and Knowledge Transfer Unit on Childhood Asthma, Research Centre, Sainte-Justine University Health Centre, Montreal, Quebec, Canada.
Ali KhamessanEuro-Pharm International Canada, Montreal, Quebec, Canada.
Benjamin VinetClinical Research and Knowledge Transfer Unit on Childhood Asthma, Research Centre, Sainte-Justine University Health Centre, Montreal, Quebec, Canada.
Centre Hospitalier Universitaire Sainte-Justine · CAUniversité de Montréal · CAMcGill University · CA

Funding

Canadian Institute of Health Research 313322, 142741
6 · The paper itself

Abstract

backgroundNew evidence supports the use of supplemental vitamin D in the prevention of exacerbation of asthma; however, the optimal posology to sufficiently raise serum levels while maximising adherence is unclear. The objective was to ascertain the efficacy of high-dose vitamin D

methodsWe conducted a 7-month, triple-blind, randomised, placebo-controlled, pilot trial of children aged 1-5 years with viral-induced asthma. Participants were allocated to receive two oral doses of 100,000 IU vitamin D

resultsChildren (N = 47) were randomised (intervention, 23; control, 24) in the fall. There was a significant adjusted group difference in the Δ25OHD (95% confidence interval) of 57.8 (47.3, 68.4) nmol/L, p < 0.0001), with a time (p < 0.0001) and group*time interaction effect (p < 0.0001), in favour of the intervention. A significant group difference in the Δ25OHD was observed 10 days after the first (119.3 [105.8, 132.9] nmol/L) and second (100.1 [85.7, 114.6] nmol/L) bolus; it did not reach statistical significance at 3.5 and 7 months. At 3.5 and 7 months, respectively, 63% and 56% of the intervention group were vitamin D sufficient (≥ 75 nmol/L) compared to 39% and 36% of the control group. Hypercalciuria, all without hypercalcaemia, was observed in 8.7% of intervention and 10.3% of control samples at any time point. Exacerbations requiring rescue oral corticosteroids, which appear as a promising primary outcome, occurred at a rate of 0.87/child.

conclusionTwo oral boluses of 100,000 IU vitamin D

trial registrationClinicalTrials.gov, NCT02197702 (23 072014). Registered on 23 July 2014.

Indexed as

Administration, OralAge FactorsAsthmaBiomarkersChild, PreschoolCholecalciferolDrug Administration ScheduleFemaleHumansInfantMalePilot ProjectsPreliminary DataQuebecSeasonsTime Factors25-hydroxyvitamin DBiomarkersCholecalciferolVitamin DAsthmaChildCholecalciferolPaediatricPilot studyRandomised controlled trialViral-inducedVitamin D

Identifiers

PMID30777118
PMCPMC6379931
OpenAlexW2917177865

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.