Evidence map›Paper›PMID 30777060›Full record

ArticleBMC biotechnology2019

Ex vivo evolution of human antibodies by CRISPR-X: from a naive B cell repertoire to affinity matured antibodies.

Marie-Claire Devilder, Melinda Moyon, Laetitia Gautreau-Rolland, Benjamin Navet, Jeanne Perroteau, Florent Delbos, Marie-Claude Gesnel, Richard Breathnach, Xavier Saulquin

Abstract read
In one paragraph

Article in BMC biotechnology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Review
  2. A Rapid Antibody Enhancement Platform inACS synthetic biology · 2023
    Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Approaches to Enhance Precise CRISPR/Cas9-Mediated Genome Editing.International journal of molecular sciences · 2021
    Review
  8. Review
  9. Full-Spectrum Targeted Mutagenesis in Plant and Animal Cells.International journal of molecular sciences · 2021
    Review
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marie-Claire DevilderCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.
Melinda MoyonCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.
Laetitia Gautreau-RollandCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.
Benjamin NavetCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.
Jeanne PerroteauCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.
Florent DelbosHLA Laboratory, EFS Centre Pays de la Loire, Nantes, France.
Marie-Claude GesnelCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France.
Richard BreathnachCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France. Richard.Breathnach@univ-nantes.fr.
Xavier SaulquinCRCINA, INSERM, CNRS, Université d'Angers, Université de Nantes, Nantes, France. xavier.saulquin@univ-nantes.fr.ORCID 0000-0002-5209-7030

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Antibody AffinityCRISPR-Cas SystemsGene EditingAntibodiesB-LymphocytesCytidine DeaminaseDirected Molecular EvolutionHEK293 CellsHLA AntigensHumansSomatic Hypermutation, ImmunoglobulinAntibodiesCytidine DeaminaseHLA AntigensAIDCRISPRCRISPR-XCytofluorimetryHLAHuman antibodiesSHMTetramers

Identifiers

PMID30777060
PMCPMC6378725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.