Evidence map›Paper›PMID 30777021›Full record

ArticleBMC medical genetics2019

A functional variant alters binding of activating protein 1 regulating expression of FGF7 gene associated with chronic obstructive pulmonary disease.

Xiaomei Zhang, Yongxin Guo, Jing Yang, Jianlou Niu, Lina Du, Haiyan Li, Xiaokun Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Xiaomei ZhangCollege of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, NO. 2888, XinCheng Avenue, Changchun, 130118, China. zhangxm130021@163.com.ORCID 0000-0002-5460-5350
Yongxin GuoCollege of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, NO. 2888, XinCheng Avenue, Changchun, 130118, China.
Jing YangCollege of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, NO. 2888, XinCheng Avenue, Changchun, 130118, China.
Jianlou NiuSchool of Pharmacy, Wenzhou Medical University, Chashan Avenue, Wenzhou, 325035, Zhejiang, China.
Lina DuCollege of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, NO. 2888, XinCheng Avenue, Changchun, 130118, China.
Haiyan LiCollege of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, NO. 2888, XinCheng Avenue, Changchun, 130118, China. hyli99@163.com.
Xiaokun LiCollege of Life Science, Engineering Research Center of the Chinese Ministry of Education for Bioreactor and Pharmaceutical Development, Jilin Agricultural University, NO. 2888, XinCheng Avenue, Changchun, 130118, China. xiaokunli@163.net.
Jilin Agricultural University · CNWenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGenome-wide association studies (GWASs) of a large cohort of subjects with chronic obstructive pulmonary disease (COPD) have successfully identified multiple risk genes, including fibroblast growth factor 7 (FGF7). However, the underlying molecular mechanism influencing function of FGF7 and risk of COPD remains further study.

methodsIn this study, we replicated the genetic association of variants near the FGF7 gene in 258 Chinese Han patients with COPD and 311 healthy controls. Additionally, we functionally evaluated a candidate causal variant upstream of the FGF7 gene.

resultsThe most significant association was observed at rs12905203 (P = 5.9 × 10

conclusionsIn this study, we demonstrated a consistent association of the FGF7 gene with COPD and mechanistically characterized a candidate functional variant upstream of the FGF7 gene. These data highlighted the important role of the risk variant and the FGF7 gene in influencing risk for COPD.

Indexed as

Polymorphism, Single NucleotideAgedCase-Control StudiesChinaFemaleFibroblast Growth Factor 7Genetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMiddle AgedProtein BindingProto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junPulmonary Disease, Chronic ObstructiveTranscription Factor AP-1FGF7 protein, humanFibroblast Growth Factor 7Proto-Oncogene Proteins c-fosProto-Oncogene Proteins c-junTranscription Factor AP-1AP-1COPDFGF7

Identifiers

PMID30777021
PMCPMC6380023
OpenAlexW2922175409

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.