ArticleBMC genomics2019
RNA-seq based transcriptional analysis of Saccharomyces cerevisiae and Lachancea thermotolerans in mixed-culture fermentations under anaerobic conditions.
Article in BMC genomics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 56 citations in OpenAlex.
- ExploringApplied and environmental microbiology · 2026Article
- Impact of direct cell-cell contact in a three-species wine yeast consortium.Applied microbiology and biotechnology · 2026Article
- Review
- Metabolic-inhibitor profiling links phenotype and transcriptome ofFood chemistry. Molecular sciences · 2025Article
- Transcriptomic responses of Saccharomyces cerevisiae and Hanseniaspora uvarum during separated co-fermentation.World journal of microbiology & biotechnology · 2025Article
- Obtaining new brewing yeasts using regional Chilean wine yeasts through an adaptive evolution program.Frontiers in microbiology · 2025Article
- Investigating the transcriptional fingerprints of coculturedFrontiers in microbiology · 2025Article
- Gradient boosted regression as a tool to reveal key drivers of temporal dynamics in a synthetic yeast community.FEMS microbiology ecology · 2024Article
- Saccharomyces cerevisiae responds similarly to co-culture or to a fraction enriched in Metschnikowia pulcherrima extracellular vesicles.Microbial biotechnology · 2023Article
- A Transcriptomic Analysis of Higher-Order Ecological Interactions in a Eukaryotic Model Microbial Ecosystem.mSphere · 2022Article
- An Integrative View of the Role ofFoods (Basel, Switzerland) · 2021Review
- Phenotypic characterization of cell-to-cell interactions between two yeast species during alcoholic fermentation.World journal of microbiology & biotechnology · 2021Article
- Understanding Wine through Yeast Interactions.Microorganisms · 2021Review
- Mechanisms Involved in Interspecific Communication between Wine Yeasts.Foods (Basel, Switzerland) · 2021Review
- Yeast Interactions and Molecular Mechanisms in Wine Fermentation: A Comprehensive Review.International journal of molecular sciences · 2021Review
- Saccharomyces cerevisiae Gene Expression during Fermentation of Pinot Noir Wines at an Industrially Relevant Scale.Applied and environmental microbiology · 2021Article
- Article
- Proteomic characterization of extracellular vesicles produced by several wine yeast species.Microbial biotechnology · 2020Article
- The Third International Symposium on Fungal Stress - ISFUS.Fungal biology · 2020Article
- Yeast-Yeast Interactions: Mechanisms, Methodologies and Impact on Composition.Microorganisms · 2020Review
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4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn wine fermentation starter cultures, the blending of non-Saccharomyces yeast with Saccharomyces cerevisiae to improve the complexity of wine has become common practice, but data regarding the impact of co-cultivation on yeast physiology and on genetic and metabolic regulation remain limited. Here we describe a transcriptomic analysis of mixed fermentations of Saccharomyces cerevisiae and Lachancea thermotolerans. The fermentations were carried out in carefully controlled environmental conditions in a bioreactor to reduce transcriptomic responses that would be due to factors other than the presence of the second species.
resultsThe transcriptomic data revealed that both yeast species showed a clear response to the presence of the other. Affected genes primarily belonged to two groups: genes whose expression can be linked to the competition for certain trace elements such as copper and iron, as well as genes required for cell wall structure and integrity. Furthermore, the data revealed divergent transcriptional responses with regard to carbon metabolism in response to anoxic conditions.
conclusionsThe results suggest that the mixed fermentation created a more competitive and stressful environment for the two species than single strain fermentations independently from total biomass, i.e. competition between cells of the same species is less stressful, or may present a different set of challenges, than interspecies competition. The changes in cell wall and adhesion properties encoding genes suggest that the adjustment of physical contact between cells may play a direct role in the response to the presence of competing species.
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