ArticlePediatric research2019
Postnatal nutritional intakes and hyperglycemia as determinants of blood pressure at 6.5 years of age in children born extremely preterm.
Article in Pediatric research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Long-Term Outcomes after Early Neonatal Hyperglycemia in VLBW Infants: A Systematic Review.Neonatology · 2021Pooled it
- Real-time continuous glucose monitoring in preterm infants (REACT): an international, open-label, randomised controlled trial.The Lancet. Child & adolescent health · 2021Trial
- Kidney health and blood pressure after very preterm birth: a cohort study at school age.Pediatric nephrology (Berlin, Germany) · 2026Article
- Early postnatal nutrition and renal consequences in preterm infants.Pediatric research · 2026Review
- Glucose disturbances in very low birth weight infants nearing term age-results from the prospective LIGHT-study using continuous glucose monitoring.European journal of pediatrics · 2025Observational
- Insulin resistance prior to term age in very low birthweight infants: a prospective study.BMJ paediatrics open · 2024Observational
- High Amino Acid Intake in Early Life Is Associated With Systolic but Not Diastolic Arterial Hypertension at 5 Years of Age in Children Born Very Preterm.Journal of the American Heart Association · 2024Article
- Hyperglycemia and prematurity: a narrative review.Pediatric research · 2023Review
- Understanding the preterm human heart: What do we know so far?Anatomical record (Hoboken, N.J. : 2007) · 2022Review
- Nutritional Approach to Prevention and Treatment of Cardiovascular Disease in Childhood.Nutrients · 2021Review
- Association between Neonatal Intakes and Hyperglycemia, and Left Heart and Aortic Dimensions at 6.5 Years of Age in Children Born Extremely Preterm.Journal of clinical medicine · 2021Article
- Right Heart Structure, Geometry and Function Assessed by Echocardiography in 6-Year-Old Children Born Extremely Preterm-A Population-Based Cohort Study.Journal of clinical medicine · 2020Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdverse developmental programming by early-life exposures might account for higher blood pressure (BP) in children born extremely preterm. We assessed associations between nutrition, growth and hyperglycemia early in infancy, and BP at 6.5 years of age in children born extremely preterm.
methodsData regarding perinatal exposures including nutrition, growth and glycemia status were collected from the Extremely Preterm Infants in Sweden Study (EXPRESS), a population-based cohort including infants born <27 gestational weeks during 2004-2007. BP measurements were performed at 6.5 years of age in a sub-cohort of 171 children (35% of the surviving children).
resultsHigher mean daily protein intake (+1 g/kg/day) during postnatal weeks 1-8 was associated with 0.40 (±0.18) SD higher diastolic BP. Higher mean daily carbohydrate intake (+1 g/kg/day) during the same period was associated with 0.18 (±0.05) and 0.14 (±0.04) SD higher systolic and diastolic BP, respectively. No associations were found between infant growth (weight, length) and later BP. Hyperglycemia and its duration during postnatal weeks 1-4 were associated primarily with higher diastolic BP z-scores.
conclusionsThese findings emphasize the importance of modifiable early-life exposures, such as nutrition and hyperglycemia, in determining long-term outcomes in children born extremely preterm.
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