ArticleCortex; a journal devoted to the study of the nervous system and behavior2019
Dopamine effects on frontal cortical blood flow and motor inhibition in Parkinson's disease.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.
- Efficacy of intermittent theta burst stimulation (iTBS) on post-stroke cognitive impairment (PSCI): a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- Comparative efficacy of transcranial magnetic stimulation on different targets in Parkinson's disease: A Bayesian network meta-analysis.Frontiers in aging neuroscience · 2022Pooled it
- Measurement of electrochemical brain activity with fast-scan cyclic voltammetry during functional magnetic resonance imaging.Nature protocols · 2026Review
- Altered cerebrovascular haemodynamics in Parkinson's disease: Insights from 4D flow MRI.NPJ Parkinson's disease · 2026Article
- Crhr1 and epinephrine utilize the central Ras-MAPK pathway in mediating the acute stress-related locomotor activity in zebrafish larvae.Frontiers in endocrinology · 2025Article
- Role of right dorsolateral prefrontal cortex-left primary motor cortex interaction in motor inhibition in Parkinson's disease.Frontiers in aging neuroscience · 2025Article
- Association between the functional connectivity of ventral tegmental area-prefrontal network and pure apathy in Parkinson's disease: a cross-sectional study.Quantitative imaging in medicine and surgery · 2024Article
- Comparison of different rhythmic auditory stimuli on prefrontal cortex cortical activation during upper limb movement in patients with Parkinson's disease: a functional near-infrared spectroscopy study.Frontiers in neurology · 2024Article
- Bradykinesia and rigidity modulated by functional connectivity between the primary motor cortex and globus pallidus in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- The Role of a Dopamine-Dependent Limbic-Motor Network in Sensory Motor Processing in Parkinson Disease.Journal of cognitive neuroscience · 2023Article
- Fully immersive virtual reality exergames with dual-task components for patients with Parkinson's disease: a feasibility study.Journal of neuroengineering and rehabilitation · 2023Article
- Combined EEG and immersive virtual reality unveil dopaminergic modulation of error monitoring in Parkinson's Disease.NPJ Parkinson's disease · 2023Article
- Dopamine-induced changes to thalamic GABA concentration in impulsive Parkinson disease patients.NPJ Parkinson's disease · 2022Article
- A literature review of dopamine in binge eating.Journal of eating disorders · 2022Review
- DThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Elevated cerebral blood flow in patients with pure autonomic failure.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2021Article
- Symptoms of Medication Withdrawal in Parkinson's Disease: Considerations for Informed Consent in Patient-Oriented Research.Pharmaceutical medicine · 2021Article
- Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs.Investigative ophthalmology & visual science · 2020Article
- Levodopa improves handwriting and instrumental tasks in previously treated patients with Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2020Article
- Self-reported rates of impulsivity in Parkinson's Disease.Annals of clinical and translational neurology · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Parkinson's disease (PD) is characterized by dysfunction in frontal cortical and striatal networks that regulate action control. We investigated the pharmacological effect of dopamine agonist replacement therapy on frontal cortical activity and motor inhibition. Using Arterial Spin Labeling MRI, we examined 26 PD patients in the off- and on-dopamine agonist medication states to assess the effect of dopamine agonists on frontal cortical regional cerebral blood flow. Motor inhibition was measured by the Simon task in both medication states. We applied the dual process activation suppression model to dissociate fast response impulses from motor inhibition of incorrect responses. General linear regression model analyses determined the medication effect on regional cerebral blood flow and motor inhibition, and the relationship between regional cerebral blood flow and motor inhibitory proficiency. We show that dopamine agonist administration increases frontal cerebral blood flow, particularly in the pre-supplementary motor area (pre-SMA) and the dorsolateral prefrontal cortex (DLPFC). Higher regional blood flow in the pre-SMA, DLPFC and motor cortex was associated with better inhibitory control, suggesting that treatments which improve frontal cortical activity could ameliorate motor inhibition deficiency in PD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.