Evidence map›Paper›PMID 30776721›Full record

ArticleSpectrochimica acta. Part A, Molecular and biomolecular spectroscopy2019

Graphene oxide as selective transporter of flavonols for physiological target DNA: A two-color fluorescence approach.

Bidisha Sengupta, Justin Coleman, John Johnson, Manliang Feng

Open access · greenAbstract read
In one paragraph

Article in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Bidisha SenguptaDepartment of Chemistry, Tougaloo College, 500 West County Line Road, Tougaloo, MS 39174, USA. Electronic address: bsengupta@tougaloo.edu.
Justin ColemanDepartment of Chemistry, Tougaloo College, 500 West County Line Road, Tougaloo, MS 39174, USA.
John JohnsonDepartment of Chemistry, Tougaloo College, 500 West County Line Road, Tougaloo, MS 39174, USA.
Manliang FengDepartment of Chemistry, Tougaloo College, 500 West County Line Road, Tougaloo, MS 39174, USA.
Tougaloo College · US

Funding

Training and Mentoring Core P20GM103476 · NIGMS · UNIVERSITY OF SOUTHERN MISSISSIPPI · PI Vijay Rangachari · 2012 to 2026
$60.2M
JACKSON HEART STUDY--TRAINING CENTERN01HC095172 · HC · TOUGALOO COLLEGE · PI SRINIVASAN, ASOKA · 1999 to 2001
$516k
Development of a humanized anti-CD47 antibody for treatment of tissue ischemia.R41HL095172 · NHLBI · VASCULOX, INC. · PI FRAZIER, WILLIAM A · 2009 to 2009
$198k
NHLBI NIH HHS N01 HC095172NIGMS NIH HHS P20 GM103476
6 · The paper itself

Abstract

Our study determines the selectivity of graphene oxide (GO) to recognize its ligands (e.g. flavonoids) in facilitating the binding with their respective cellular targets. The polyhydroxy phenolic compounds, flavonoids, have a broad spectrum of therapeutic activities with high potency and low systemic toxicity. Despite the vast medicinal importance, their bioavailability is low. In this exploratory study, GO has been used as the transporter of three flavonols fisetin (3, 7, 3', 4'-OH flavone), quercetin (3, 5, 7, 3', 4'-OH flavone), and morin (3, 5, 7, 2', 4'-OH flavone) for the physiological target DNA. Calf thymus DNA is chosen as the model physiological target. Characterization of GO is performed using FTIR, Raman and dynamic light scattering (DLS) spectroscopy. The strong absorption peak at 1730 cm

Indexed as

AnimalsCattleDNADrug CarriersFlavonolsGraphiteSpectrometry, FluorescenceSpectroscopy, Fourier Transform InfraredSpectrum Analysis, Ramancalf thymus DNADNADrug CarriersFlavonolsgraphene oxideGraphiteCircular dichroismDynamic light scatteringExcited-state intramolecular proton transferFlavonoidsFluorescence anisotropy

Identifiers

PMID30776721
PMCPMC6869337
OpenAlexW2914379429

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.