ArticleCancer epidemiology2019
Parental age and the risk of childhood acute myeloid leukemia: results from the Childhood Leukemia International Consortium.
Article in Cancer epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of size at birth on health, growth and developmental outcomes in children up to age 18: an umbrella review.Archives of disease in childhood · 2023Pooled it
- Parental Age and Childhood Lymphoma and Solid Tumor Risk: A Literature Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- The Childhood Cancer and Leukemia International Consortium (CLIC): Expanding global collaboration in pediatric cancer etiology research.Cancer epidemiology · 2026Review
- Maternal smoking and risk of childhood cancer: a report from the Childhood Cancer and Leukemia International Consortium.International journal of epidemiology · 2026Article
- Causes of Childhood Cancer: A Review of Literature (2014-2021): Part 2-Pregnancy and Birth-Related Factors.Cancers · 2025Review
- Review
- Nonchromosomal birth defects and risk of childhood acute leukemia: An assessment in 15 000 leukemia cases and 46 000 controls from the Childhood Cancer and Leukemia International Consortium.International journal of cancer · 2024Article
- In Utero Origins of Acute Leukemia in Children.Biomedicines · 2024Review
- Counts, incidence rates, and trends of pediatric cancer in the United States, 2003-2019.Journal of the National Cancer Institute · 2023Article
- Developmental origins of health and disease: Impact of paternal nutrition and lifestyle.Pediatric investigation · 2023Review
- Pediatric Cancer By Race, Ethnicity and Region in the United States.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2022Article
- Infant feeding practices and childhood acute leukemia: Findings from the Childhood Cancer & Leukemia International Consortium.International journal of cancer · 2022Article
- Medication-Associated Phthalate Exposure and Childhood Cancer Incidence.Journal of the National Cancer Institute · 2022Article
- Persistently high incidence rates of childhood acute leukemias from 2010 to 2017 in Mexico City: A population study from the MIGICCL.Frontiers in public health · 2022Article
- Birth characteristics and childhood leukemia in Switzerland: a register-based case-control study.Cancer causes & control : CCC · 2021Article
- Comparison of Incidence and Outcomes of Neuroblastoma in Children, Adolescents, and Adults in the United States: A Surveillance, Epidemiology, and End Results (SEER) Program Population Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Advanced paternal age: effects on sperm parameters, assisted reproduction outcomes and offspring health.Reproductive biology and endocrinology : RB&E · 2020Review
- Air pollution exposure at the residence and risk of childhood cancers in Denmark: A nationwide register-based case-control study.EClinicalMedicine · 2020Article
- LncRNAOncoTargets and therapy · 2020Article
Corrections and comments
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Authors and funding
27 authors.
Funding
Abstract
backgroundParental age has been associated with several childhood cancers, albeit the evidence is still inconsistent.
aimTo examine the associations of parental age at birth with acute myeloid leukemia (AML) among children aged 0-14 years using individual-level data from the Childhood Leukemia International Consortium (CLIC) and non-CLIC studies. MATERIAL/
methodsWe analyzed data of 3182 incident AML cases and 8377 controls from 17 studies [seven registry-based case-control (RCC) studies and ten questionnaire-based case-control (QCC) studies]. AML risk in association with parental age was calculated using multiple logistic regression, meta-analyses, and pooled-effect estimates. Models were stratified by age at diagnosis (infants <1 year-old vs. children 1-14 years-old) and by study design, using five-year parental age increments and controlling for sex, ethnicity, birthweight, prematurity, multiple gestation, birth order, maternal smoking and education, age at diagnosis (cases aged 1-14 years), and recruitment time period.
resultsAdjusted odds ratios (ORs) and 95% confidence intervals (CIs) derived from RCC, but not from the QCC, studies showed a higher AML risk for infants of mothers ≥40-year-old (OR = 6.87; 95% CI: 2.12-22.25). There were no associations observed between any other maternal or paternal age group and AML risk for children older than one year.
conclusionsAn increased risk of infant AML with advanced maternal age was found using data from RCC, but not from QCC studies; no parental age-AML associations were observed for older children.
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