ArticleMicrobial pathogenesis2019
House dust mite exposure attenuates influenza A infection in a mouse model of pulmonary allergic inflammation.
Article in Microbial pathogenesis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Respiratory tract infections in children with allergic asthma on allergen immunotherapy during influenza season.Scientific reports · 2021Article
- Influenza virus-flow from insects to humans as causative for influenza seasonality.Biology direct · 2020Article
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Environmental allergens elicit complex immune responses in the lungs that can promote the development of asthma or exacerbate preexisting asthma in susceptible individuals. House dust mites are one of the most common indoor allergens and are a significant driver of allergic disease. Respiratory infections are known factors in acute exacerbations of asthma but the impact of allergen on the pathogen is not well understood. We investigated the pathogenesis of influenza A infection following exposure to house dust mites. Mice exposed to house dust mites lose less weight following infection and had more transcription of interferon-lambda than controls. These data correlated with less transcription of the influenza polymerase acidic gene suggesting diminished viral replication in house dust mite exposed mice. Altogether, these data suggest that exposure to environmental allergens can influence the pathogenesis of influenza infection.
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Registered trials
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