ArticleThe Journal of infectious diseases2019
Infection Studies in Pigs and Porcine Airway Epithelial Cells Reveal an Evolution of A(H1N1)pdm09 Influenza A Viruses Toward Lower Virulence.
Article in The Journal of infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Beyond H5N1: influenza A virus infection in bovine udder organoids.Emerging microbes & infections · 2026Article
- Efficient replication of avian, porcine and human influenza A viruses in well-differentiated bovine airway epithelial cells.Emerging microbes & infections · 2025Article
- The Originally Established PBE Cell Line as a Reliable In Vitro Model for Investigating SIV Infection and Immunity.International journal of molecular sciences · 2025Article
- Reassortment incompetent live attenuated and replicon influenza vaccines provide improved protection against influenza in piglets.NPJ vaccines · 2024Article
- Pandemic Risk Assessment for Swine Influenza A Virus in Comparative In Vitro and In Vivo Models.Viruses · 2024Article
- Article
- Establishment of a porcine bronchial epithelial cell line and its application to study innate immunity in the respiratory epithelium.Frontiers in immunology · 2023Article
- Article
- Time-dependent viral interference between influenza virus and coronavirus in the infection of differentiated porcine airway epithelial cells.Virulence · 2021Article
- Infection of polarized bovine respiratory epithelial cells by bovine viral diarrhea virus (BVDV).Virulence · 2021Article
- Infection of bovine well-differentiated airway epithelial cells by Pasteurella multocida: actions and counteractions in the bacteria-host interactions.Veterinary research · 2020Article
- Zoonotic infection with swine A/H1Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2020Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed the virulence of pandemic H1N1 2009 influenza A viruses in vivo and in vitro. Selected viruses isolated in 2009, 2010, 2014, and 2015 were assessed using an aerosol-mediated high-dose infection model for pigs as well as air-liquid interface cultures of differentiated airway epithelial cells. Using a dyspnea score, rectal temperature, lung lesions, and viral load in the lung as parameters, the strains from 2014-2015 were significantly less virulent than the strains isolated in 2009-2010. In vitro, the viruses from 2009-2010 also differed from the 2014-2015 viruses by increased release of infectious virus, a more pronounced loss of ciliated cells, and a reduced thickness of the epithelial cell layer. Our in vivo and in vitro results reveal an evolution of A(H1N1)pdm09 viruses toward lower virulence. Our in vitro culture system can be used to predict the virulence of influenza viruses.
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