Evidence map›Paper›PMID 30776137›Full record

ReviewClinical transplantation2019

Parvovirus B19-induced severe anemia in heart transplant recipients: Case report and review of the literature.

Natalia C Pinto, Clarissa Newman, Carlos A Gomez, Kiran K Khush, Yasbanoo Moayedi, Roy Lee, Jeffrey J Teuteberg, Jose G Montoya

Open access · hybridAbstract readCase ReportsReview
In one paragraph

Review in Clinical transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Parvovirus in cardiac transplant: our experience.Indian journal of thoracic and cardiovascular surgery · 2025
    Article
  3. Article
  4. Article
  5. A Case with Iron Deficiency Anemia Developed Aplastic Crisis.The Kobe journal of medical sciences · 2022
    Article
  6. Structures and implications of the nuclease domain of human parvovirus B19 NS1 protein.Computational and structural biotechnology journal · 2022
    Article
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Natalia C PintoDepartment of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.
Clarissa NewmanDepartment of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.
Carlos A GomezDepartment of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.ORCID 0000-0001-5486-5710
Kiran K KhushDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California.
Yasbanoo MoayediDepartment of Medicine, Section of Heart Failure, Cardiac Transplant, and Mechanical Circulatory Support, Stanford University, Stanford, California.ORCID 0000-0002-3288-7393
Roy LeeDepartment of Pharmacy and Department of Heart and Lung Transplantation, Stanford University School of Medicine, Stanford, California.
Jeffrey J TeutebergDepartment of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California.
Jose G MontoyaDepartment of Medicine and Division of Infectious Diseases and Geographic Medicine, Stanford University School of Medicine, Stanford, California.
Stanford Medicine · USUniversity Health Network · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of a 64-year-old woman who developed transfusion-dependent anemia after cardiac transplantation, the etiology of which was unknown after initial comprehensive evaluation. At the suggestion of the Transplant Infectious Diseases consultant, microbial agents with red blood cell tropism pertinent to this patient such as Parvovirus B 19 (B19V) were investigated. The B19V viral load by PCR in peripheral blood was >100 000 000 copies/ml and after treatment with intravenous immunoglobulin (IVIG), her anemia resolved. Here, we summarize the clinical and virologic characteristics, treatment, and outcome of fifteen cases of B19V-induced anemia in heart transplant recipients. Spontaneous recovery from anemia secondary to B19V has also been reported in some heart transplant recipients, possibly due to an absence of their B19V P-antigen receptor and/or reduction in their immunosuppression. Therefore, in heart transplant patients, B19V should be suspected early as a cause of severe anemia of unknown etiology. The extent that B19V-induced anemia is underdiagnosed in heart transplant recipients is unknown.

Indexed as

AnemiaFemaleHeart TransplantationHumansMiddle AgedParvoviridae InfectionsParvovirus B19, HumanPrognosisViral Loadanemiaheart transplantationintravenous immunoglobulinParvovirus B19

Identifiers

PMID30776137
PMCPMC6850585
OpenAlexW2917813788

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.