ArticleJournal of Alzheimer's disease : JAD2019
Connectivity Between Brain Networks Dynamically Reflects Cognitive Status of Parkinson's Disease: A Longitudinal Study.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Eight-year longitudinal changes in functional connectivity of the fatigue network in Parkinson's disease: evidence from four timepoints.Brain imaging and behavior · 2026Article
- A coarse-to-fine machine-learning framework for identifying functional connectivity markers of cognitive impairment in Parkinson's disease.Medical & biological engineering & computing · 2026Article
- The phase average wavelength of alpha rhythm in EEG signals of patients with Parkinson's disease combined with cognitive impairment.PloS one · 2026Article
- Structural covariance network alterations across the spectrum of cognitive status in Parkinson's disease.Clinical parkinsonism & related disorders · 2026Review
- Cortical connectivity is associated with cognition across time in Parkinson's disease.Neuroimage. Reports · 2025Article
- Deep learning and whole-brain networks for biomarker discovery: modeling the dynamics of brain fluctuations in resting-state and cognitive tasks.Scientific reports · 2025Article
- Longitudinal Multimodal Functional Imaging: An Essential Tool for Visualizing Pathologic Progression in Parkinson's Disease.Journal of movement disorders · 2025Article
- A signature combining brain functional connectivity with executive and motor function for general cognitive decline in Parkinson's disease.Frontiers in neurology · 2025Article
- Changes of neural coupling between cognitive and motor networks associated with dual-task performance in Parkinson's disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Computational Neurosurgery in Deep Brain Stimulation.Advances in experimental medicine and biology · 2024Review
- Mild cognitive impairment in Parkinson's disease: current view.Frontiers in cognition · 2024Review
- Functional neural networks stratify Parkinson's disease patients across the spectrum of cognitive impairment.Brain and behavior · 2024Article
- Different pieces of the same puzzle: a multifaceted perspective on the complex biological basis of Parkinson's disease.NPJ Parkinson's disease · 2023Review
- Toward an Understanding of Healthy Cognitive Aging: The Importance of Lifestyle in Cognitive Reserve and the Scaffolding Theory of Aging and Cognition.The journals of gerontology. Series B, Psychological sciences and social sciences · 2023Review
- Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Alterations in Large-Scale Intrinsic Connectivity Networks in the Parkinson's Disease-Associated Cognitive Impairment Continuum: A Systematic Review.Noro psikiyatri arsivi · 2022Review
- Internetwork Connectivity Predicts Cognitive Decline in Parkinson's and Is Altered by Genetic Variants.Frontiers in aging neuroscience · 2022Article
- Reduced Effective Connectivity in the Motor Cortex in Parkinson's Disease.Brain sciences · 2021Article
- Cognitive impairment in Parkinson's disease is associated with Default Mode Network subsystem connectivity and cerebrospinal fluid Aβ.Parkinsonism & related disorders · 2021Article
- Spatial Stability of Functional Networks: A Measure to Assess the Robustness of Graph-Theoretical Metrics to Spatial Errors Related to Brain Parcellation.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment in Parkinson's disease (PD) is associated with altered connectivity of the resting state networks (RSNs). Longitudinal studies in well cognitively characterized PD subgroups are missing.
objectivesTo assess changes of the whole-brain connectivity and between-network connectivity (BNC) of large-scale functional networks related to cognition in well characterized PD patients using a longitudinal study design and various analytical methods.
methodsWe explored the whole-brain connectivity and BNC of the frontoparietal control network (FPCN) and the default mode, dorsal attention, and visual networks in PD with normal cognition (PD-NC, n = 17) and mild cognitive impairment (PD-MCI, n = 22) as compared to 51 healthy controls (HC). We applied regions of interest-based, partial least squares, and graph theory based network analyses. The differences among groups were analyzed at baseline and at the one-year follow-up visit (37 HC, 23 PD all).
resultsThe BNC of the FPCN and other RSNs was reduced, and the whole-brain analysis revealed increased characteristic path length and decreased average node strength, clustering coefficient, and global efficiency in PD-NC compared to HC. Values of all measures in PD-MCI were between that of HC and PD-NC. After one year, the BNC was further increased in the PD-all group; no changes were detected in HC. No cognitive domain z-scores deteriorated in either group.
conclusionAs compared to HC, PD-NC patients display a less efficient transfer of information globally and reduced BNC of the visual and frontoparietal control network. The BNC increases with time and MCI status, reflecting compensatory efforts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.