Evidence map›Paper›PMID 30775987›Full record

ArticleJournal of Alzheimer's disease : JAD2019

Antiepileptic Drug Use Is Associated with an Increased Risk of Pneumonia Among Community-Dwelling Persons with Alzheimer's Disease-Matched Cohort Study.

Heidi Taipale, Pasi Lampela, Marjaana Koponen, Antti Tanskanen, Jari Tiihonen, Sirpa Hartikainen, Anna-Maija Tolppanen

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Heidi TaipaleKuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland.
Pasi LampelaKuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland.
Marjaana KoponenKuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland.
Antti TanskanenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Jari TiihonenDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Sirpa HartikainenKuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland.
Anna-Maija TolppanenSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.
University of Eastern Finland · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntiepileptic drugs (AEDs) have sedative properties which may lead to an increased risk of pneumonia.

objectivesTo investigate whether incident AED use is associated with an increased risk of pneumonia among community-dwelling persons with Alzheimer's disease (AD). In addition, we determined the risk according to duration of AED use and specific AEDs.

methodsPersons with AD were identified from the MEDALZ dataset which includes all community-dwelling persons who received a clinically verified diagnosis of AD during 2005-2011 in Finland (N=70,718). New AED users were identified with one-year washout period. A matched cohort (1 : 1, N=5,769, matching criteria age, gender, and time since AD diagnoses) of nonusers was formed. Data from nationwide registers included dispensed medications which were modelled with PRE2DUP method, hospitalizations, and causes of death. The association between AED use and hospital admission or death due to pneumonia was analyzed with Cox proportional hazard models.

resultsAED use was associated with an increased risk of pneumonia (adjusted HR 1.92, 95% CI 1.63-2.26; incidence rate per 100 person-years 12.58, 95% CI 12.49-12.66 during AED use and 6.41, 95% CI 6.37-6.45 during nonuse). The highest risk was observed during the first month of use (aHR 3.59, 95% CI 2.29-5.61) and the risk remained elevated until two years of use. Of specific drug substances, phenytoin, carbamazepine, valproic acid, and pregabalin were associated with an increased risk.

conclusionAntiepileptic drug use may increase the risk of pneumonia which is concerning as persons with AD have elevated risk of pneumonia.

Indexed as

Independent LivingAgedAged, 80 and overAlzheimer DiseaseAnticonvulsantsCohort StudiesFemaleFinlandFollow-Up StudiesHumansMaleMiddle AgedPneumoniaResearch DesignRisk FactorsAnticonvulsantsAlzheimer’s diseaseanticonvulsantantiepilepticdementiamood stabilizerolder personpharmacoepidemiologypneumonia

Identifiers

PMID30775987
PMCPMC6484268
OpenAlexW2911977536

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.