ArticleJournal of Alzheimer's disease : JAD2019
Modifiable Risk Factors Discriminate Memory Trajectories in Non-Demented Aging: Precision Factors and Targets for Promoting Healthier Brain Aging and Preventing Dementia.
Article in Journal of Alzheimer's disease : JAD, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Joint changes in subjective memory and objective cognition and risk of incident functional dependence: A harmonized analysis of four aging cohorts.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- A roadmap for conducting more inclusive research on brain resilience in ageing and dementia.Nature reviews. Neuroscience · 2026Review
- Evaluating sex and gender as separate and interactive predictors of memory aging trajectory classes: an integrative data-driven approach.Biology of sex differences · 2026Article
- Gaps in Population Life Course Phenotype Trajectories Underlying Major Noncommunicable Diseases: A Scoping Review.International journal of population data science · 2026Article
- Identifying lifestyle risk factors that discriminate memory trajectories: Differential findings across racial and ethnic groups in older adults.Neurobiology of aging · 2025Article
- The impact of lifestyle factors on trajectories of cognitive subtypes in the older adult population.Scientific reports · 2025Article
- Cumulative blood pressure load and cognitive decline in older adults: An observational analysis of two large cohorts.Cerebral circulation - cognition and behavior · 2025Article
- Advancements in deep learning for early diagnosis of Alzheimer's disease using multimodal neuroimaging: challenges and future directions.Frontiers in neuroinformatics · 2025Review
- Does the positive association between social relationships and cognition continue until very old age?European journal of ageing · 2024Article
- Article
- A Subtype Perspective on Cognitive Trajectories in Healthy Aging.Brain sciences · 2024Article
- Gender Selectively Mediates the Association Between Sex and Memory in Cognitively Normal Older Adults.Innovation in aging · 2024Article
- Machine learning analyses identify multi-modal frailty factors that selectively discriminate four cohorts in the Alzheimer's disease spectrum: a COMPASS-ND study.BMC geriatrics · 2023Article
- Hippocampal connectivity and memory decline in cognitively intact APOE ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Association of Brain Age, Lesion Volume, and Functional Outcome in Patients With Stroke.Neurology · 2023Observational
- Article
- Decreased visual acuity is related to thinner cortex in cognitively normal adults: cross-sectional, single-center cohort study.Alzheimer's research & therapy · 2022Article
- Subjective memory concerns, poor vascular health, and male sex predict exacerbated memory decline trajectories: An integrative data-driven class and prediction analysis.Neuropsychology · 2022Article
- The adverse effect of modifiable dementia risk factors on cognition amplifies across the adult lifespan.Alzheimer's & dementia (Amsterdam, Netherlands) · 2022Article
- Potential modifiable factors associated with late-life cognitive trajectories.Frontiers in neurology · 2022Article
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3 authors.
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Abstract
backgroundNon-demented cognitive aging trajectories are characterized by vast level and slope differences and a spectrum of outcomes, including dementia.
objectiveThe goal of AD risk management (and its corollary, promoting healthy brain aging) is aided by two converging objectives: 1) classifying dynamic distributions of non-demented cognitive trajectories, and 2) identifying modifiable risk-elevating and risk-reducing factors that discriminate stable or normal trajectory patterns from declining or pre-impairment patterns.
methodUsing latent class growth analysis we classified three episodic memory aging trajectories for n = 882 older adults (baseline Mage=71.6, SD=8.9, range = 53-95, female=66%): Stable (SMA; above average level, sustained slope), Normal (NMA; average level, moderately declining slope), and Declining (DMA; below average level, substantially declining slope). Using random forest analyses, we simultaneously assessed 17 risk/protective factors from non-modifiable demographic, functional, psychological, and lifestyle domains. Within two age strata (Young-Old, Old-Old), three pairwise prediction analyses identified important discriminating factors.
resultsPrediction analyses revealed that different modifiable risk predictors, both shared and unique across age strata, discriminated SMA (i.e., education, depressive symptoms, living status, body mass index, heart rate, social activity) and DMA (i.e., lifestyle activities [cognitive, self-maintenance, social], grip strength, heart rate, gait) groups.
conclusionMemory trajectory analyses produced empirical classes varying in level and slope. Prediction analyses revealed different predictors of SMA and DMA that also varied by age strata. Precision approaches for promoting healthier memory aging-and delaying memory impairment-may identify modifiable factors that constitute specific targets for intervention in the differential context of age and non-demented trajectory patterns.
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