ArticleJournal of biomedical materials research. Part B, Applied biomaterials2019
In vivo comparison of shape memory polymer foam-coated and bare metal coils for aneurysm occlusion in the rabbit elastase model.
Article in Journal of biomedical materials research. Part B, Applied biomaterials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
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Who cites it
22 citing papers in PubMed, 43 citations in OpenAlex.
- Trial
- In-Vitro Evaluations of Shape Memory Polymer Scaffolds With Tunable Architecture for the Endovascular Embolization of Unruptured Intracranial Aneurysms.Journal of biomechanical engineering · 2026Article
- Expandable Nanocomposite Shape-Memory Hemostat for the Treatment of Noncompressible Hemorrhage.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Biomechanics and modeling in mechanobiology · 2025Article
- CFD investigations of a shape-memory polymer foam-based endovascular embolization device for the treatment of intracranial aneurysms.Research square · 2024Article
- Advances and applications of biomimetic biomaterials for endogenous skin regeneration.Bioactive materials · 2024Review
- Development of Biopsy Tract Sealants Based on Shape Memory Polymer Foams.Biomedical materials & devices (New York, N.Y.) · 2023Article
- A novel self-expanding shape memory polymer coil for intracranial aneurysm embolization: 1 year follow-up in Chile.Journal of neurointerventional surgery · 2023Article
- Image-Based Evaluation of In Vivo Degradation for Shape-Memory Polymer Polyurethane Foam.Polymers · 2022Article
- Macrophage activation in response to shape memory polymer foam-coated aneurysm occlusion devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Shape Memory Polymer-Based Endovascular Devices: Design Criteria and Future Perspective.Polymers · 2022Review
- Article
- Rabbit Elastase Aneurysm Model Mimics the Recurrence Rate of Human Intracranial Aneurysms following Platinum Coil Embolization.AJNR. American journal of neuroradiology · 2022Article
- Bioactive refinement for endosaccular treatment of intracranial aneurysms.The neuroradiology journal · 2021Review
- Article
- Biobased polyurethanes for biomedical applications.Bioactive materials · 2021Review
- In situ decellularization of a large animal saccular aneurysm model: sustained inflammation and active aneurysm wall remodeling.Journal of neurointerventional surgery · 2021Article
- The Distribution and Role of M1 and M2 Macrophages in Aneurysm Healing after Platinum Coil Embolization.AJNR. American journal of neuroradiology · 2020Article
- Micro-CT and histopathology methods to assess host response of aneurysms treated with shape memory polymer foam-coated coils versus bare metal coil occlusion devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2020Article
- Microscopic Assessment of Healing and Effectiveness of a Foam-Based Peripheral Occlusion Device.ACS biomaterials science & engineering · 2020Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
Abstract
Shape memory polymer (SMP) foam-coated coils (FCCs) are new embolic coils coated with porous SMP designed to expand for increased volume filling and enhanced healing after implantation. The purpose of this study was to compare chronic aneurysm healing after treatment with SMP FCCs to bare platinum coil (BPC) controls in the rabbit elastase aneurysm model. BPCs or SMP FCCs were implanted in rabbit elastase-induced aneurysms for follow-up at 30 days (n = 10), 90 days (n = 5), and 180 days (n = 12 for BPCs; n = 14 for SMP FCCs). Aneurysm occlusion and histologic healing, including a qualitative healing score, neointima thickness, collagen deposition, and inflammation were compared between the two groups. The mean neointima thickness was significantly greater in groups treated with SMP FCCs for all three time points. Histologic healing scores and collagen deposition quantification suggested that aneurysms treated with SMP FCCs experience more complete healing of the dome by 90 days, but the differences were not statistically significant. More progressive occlusion and recanalization were observed in aneurysms treated with SMP FCCs, but neither difference was statistically significant. Additionally, the SMP foam used in the FCCs was found to degrade faster in the rabbit elastase model than expected based on previous studies in a porcine sidewall aneurysm model. This study suggests that SMP FCCs can promote neointima formation along the aneurysm neck, and may lead to more complete healing of the dome and neck. These findings indicate potential benefits of this device for aneurysm occlusion procedures. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2466-2475, 2019.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.