Evidence map›Paper›PMID 30775701›Full record

ReviewWorld journal of otorhinolaryngology - head and neck surgery2019

The outcomes of hypoglossal nerve stimulation in the management of OSA: A systematic review and meta-analysis.

Anvesh R Kompelli, Jonathan S Ni, Shaun A Nguyen, Eric J Lentsch, David M Neskey, Ted A Meyer

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of otorhinolaryngology - head and neck surgery, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 3 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 3 syntheses or guidelines pooled it, 50 citations in OpenAlex.

  1. Effect of norepinephrine reuptake inhibitors combined with antimuscarinic agents vs monotherapy for OSA: a systematic review and meta-analysis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Pooled it
  2. Patient-reported outcomes with hypoglossal nerve stimulation for treatment of obstructive sleep apnea: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023
    Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Chinese Guidelines for the Diagnosis and Surgical Treatment of Adult Obstructive Sleep Apnea (2024).World journal of otorhinolaryngology - head and neck surgery · 2026
    Article
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  8. Article
  9. Article
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  11. The role of positional changes in optimizing OSA treatment: evidence from DISE.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2025
    Article
  12. Article
  13. International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023
    Review
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  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Anvesh R KompelliDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Jonathan S NiDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Shaun A NguyenDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Eric J LentschDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
David M NeskeyDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Ted A MeyerDepartment of Otolaryngology - Head and Neck Surgery, Medical University of South Carolina, Charleston, SC, USA.
Medical University of South Carolina · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesObstructive sleep apnea (OSA) is a prevalent disease with significant health impacts. While first line therapy is CPAP, long-term compliance is low and device misuse is common, highlighting the need for alternative therapies. Upper airway surgery is one alternative, but substantial side effects hamper efficacy. A new alternative is an implantable hypoglossal nerve stimulator (HNS). These devices utilize neuromodulation to dilate/reinforce the airway and reduce side effects associated with traditional surgery. Several recent trials investigated the efficacy of these devices. The purpose of this study was to perform meta-analysis of available HNS studies investigating treatment of OSA to analyze objective and subjective outcomes and side effects.

methodsA comprehensive literature search of PubMed and Scopus was performed. Two independent reviewers examined clinical trials investigating HNS in treatment of sleep apnea in adults. Studies with objective and subjective endpoints in sleep were included for analysis. Adverse events from trials were also recorded.

resultsAcross 16 studies, 381 patients were analyzed. At 6 months (

conclusionsHNS is a safe and effective treatment for CPAP refractory OSA. Further study comparing HNS to other therapies is required.

Indexed as

Obstructive sleep apneaSleep medicineSurgical treatment of obstructive sleep apnea

Identifiers

PMID30775701
PMCPMC6364516
OpenAlexW2893948852

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.