Evidence map›Paper›PMID 30775619›Full record

ArticleKidney international reports2019

Depressive Symptoms Associate With Race and All-Cause Mortality in Patients With CKD.

Delphine S Tuot, Feng Lin, Keith Norris, Jennifer Gassman, Miroslaw Smogorzewski, Elaine Ku

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Kidney international reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Article
  2. Review
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  13. Incidence and Risk Factors for Pruritus in Patients with Nondialysis CKD.Clinical journal of the American Society of Nephrology : CJASN · 2023
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Religious Service Attendance and Mortality among Adults in the United States with Chronic Kidney Disease.International journal of environmental research and public health · 2021
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Delphine S TuotDivision of Nephrology, University of California, San Francisco; San Francisco, California, USA.
Feng LinDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA.
Keith NorrisUniversity of California, Los Angeles, Los Angeles, California, USA.
Jennifer GassmanCleveland Clinic Foundation, Cleveland, Ohio, USA.
Miroslaw SmogorzewskiUniversity of Southern California, Los Angeles, Los Angeles, California, USA.
Elaine KuDivision of Nephrology, University of California, San Francisco; San Francisco, California, USA.

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
The Center for Health Improvement of Minority ElderlyP30AG021684 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CATHERINE A SARKISIAN · 2002 to 2026
$19.7M
TRAINING COREP20MD000182 · NIMHD · CHARLES R. DREW UNIVERSITY OF MED &SCI · PI MILBURN, NORWEETA GERMAINE, SHAPIRO, MARTIN F. · 2002 to 2016
$16.5M
Kidney Awareness Registry and Education-2R01DK104130 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI TUOT, DELPHINE · 2015 to 2019
$2.8M
Blood pressure trends, outcomes, and interventions in adolescents and young adults at increased cardiovascular riskK23HL131023 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KU, ELAINE · 2016 to 2020
$991k
NCATS NIH HHS UL1 TR000124NHLBI NIH HHS K23 HL131023NIA NIH HHS P30 AG021684NIDDK NIH HHS R01 DK104130NIMHD NIH HHS P20 MD000182
6 · The paper itself

Abstract

introductionDepression is common but underrecognized in patients with chronic kidney disease (CKD), especially among racial/ethnic minorities. We examined the association between depressive symptoms and all-cause mortality (including deaths before and after end-stage renal disease [ESRD]) and whether antidepressant use impacts this association, overall, and by race/ethnicity.

methodsWe ascertained whether the presence of depressive symptoms, defined by a Beck Depression Inventory II (BDI) score of >14 at cohort enrollment, was associated with all-cause mortality (before or after ESRD) among study participants of the Chronic Renal Insufficient Cohort (CRIC) overall and by race/ethnicity. Models were adjusted for socioeconomic factors, baseline CKD severity, time-updated comorbid conditions, and time-updated antidepressant use. Confirmatory analyses were performed among African American Study of Kidney Disease and Hypertension (AASK) participants.

resultsAmong 3739 CRIC participants, 16.3% had a baseline BDI of >14; 18.2% reported antidepressant use. Crude mortality rate was 3.16 per 100 person-years during 6.8 years of median follow-up. Baseline BDI >14 was independently associated with higher risk of all-cause mortality (adjusted hazard ratio [aHR]: 1.27; 95% confidence interval: 1.07-1.52) without attenuation by antidepressant use. Differences among white and black individuals were noted (P

conclusionsThe presence of depressive symptoms is a risk factor for all-cause mortality among patients with mild-moderate CKD, particularly among white individuals. Further studies are needed to understand the heterogeneity in the response to the presence of depressive symptoms by race.

Indexed as

AASKchronic kidney diseaseCKDCRICdepressionmortality

Identifiers

PMID30775619
PMCPMC6365404

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.