ArticleOsteoporosis and sarcopenia2016
Combined treatment with minodronate and vitamin C increases bone mineral density and strength in vitamin C-deficient rats.
Article in Osteoporosis and sarcopenia, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Role of vitamins beyond vitamin DInternational journal of molecular medicine · 2024Review
- Teriparatide and exercise improve bone, skeletal muscle, and fat parameters in ovariectomized and tail-suspended rats.Journal of bone and mineral metabolism · 2021Article
- Effects of bazedoxifene and low-intensity aerobic exercise on bone and fat parameters in ovariectomized rats.Journal of bone and mineral metabolism · 2020Article
- Impact of vitamin C on teriparatide treatment in the improvement of bone mineral density, strength, and quality in vitamin C-deficient rats.Journal of bone and mineral metabolism · 2019Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesReduced bone quality caused by vitamin C deficiency in older persons may lead to incidental fragility fractures during bisphosphonate treatment, although bisphosphonate increases bone mineral density (BMD). This study aimed to evaluate the effects of minodronate and ascorbic acid (Aa) on BMD, bone quality, and bone strength in Aa-deficient osteogenic disorder Shionogi (ODS) rats.
methodsSix-month-old ODS rats were divided into four groups (n = 20 per group): (1) Aa supplementation (Aa
resultsBMD was significantly higher in the Aa
conclusionsAa supplementation improved bone strength in ODS rats. Combined treatment with minodronate and Aa, but not minodronate alone, improved bone strength and increased BMD. Aa is required for bone health because it is essential for osteoblast differentiation.
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Registered trials
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