Evidence map›Paper›PMID 30775420›Full record

ArticleChronic obstructive pulmonary diseases (Miami, Fla.)2018

Costs of Medical Care Among Augmentation Therapy Users and Non-Users with Alpha-1 Antitrypsin Deficiency in the United States.

Jan Sieluk, Joseph Levy, Robert A Sandhaus, Henry Silverman, Kristen E Holm, C Daniel Mullins

Registry-linked trialOpen access · diamondAbstract read
In one paragraph

Article in Chronic obstructive pulmonary diseases (Miami, Fla.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07715617 (Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency), which is not on this map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07715617 recruitingnot on this mapstarted 2026, after this paper: background citation

Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency

TypeobservationalSponsorUniversity Hospital, BordeauxRan2026 to 2031Enrolled230ConditionsAlpha-1-antitrypsin Deficiency, Emphysema, Artificial Intelligence (AI), Predictive Learning Models
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Disease burden associated with alpha-1 antitrypsin deficiency: systematic and structured literature reviews.European respiratory review : an official journal of the European Respiratory Society · 2022
    Pooled it
  2. Review
  3. Article
  4. Testing Alpha-1 Antitrypsin Deficiency in Black Populations.Advances in respiratory medicine · 2023
    Review
  5. Observational
  6. Review
  7. Clarifying the Risk of Lung Disease in SZ Alpha-1 Antitrypsin Deficiency.American journal of respiratory and critical care medicine · 2020
    Observational
  8. Alpha-1 Antitrypsin Deficiency: a Rare Disease?Current allergy and asthma reports · 2020
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jan SielukPharmaceutical Health Services Research Department, School of Pharmacy, University of Maryland, Baltimore.
Joseph LevyPharmaceutical Health Services Research Department, School of Pharmacy, University of Maryland, Baltimore.
Robert A SandhausDivision of Pulmonary, Critical Care and Sleep Medicine, National Jewish Health, Denver, Colorado.
Henry SilvermanSchool of Medicine, University of Maryland, Baltimore.
Kristen E HolmDivision of Medical, Behavioral, and Community Health, National Jewish Health, Denver, Colorado.
C Daniel MullinsPharmaceutical Health Services Research Department, School of Pharmacy, University of Maryland, Baltimore.
University of Maryland, Baltimore · USNational Jewish Health · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

alpha-1 antitrypsin deficiencyaugmentation therapychronic obstructive pulmonary diseasemedical costspharmacoeconomics

Identifiers

PMID30775420
PMCPMC6373584
OpenAlexW2903315918

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.