Evidence map›Paper›PMID 30775417›Full record

ArticleAlzheimer's & dementia (New York, N. Y.)2019

From brain collections to modern brain banks: A historical perspective.

Arenn Faye Carlos, Tino Emanuele Poloni, Valentina Medici, Maia Chikhladze, Antonio Guaita, Mauro Ceroni

Open access · goldAbstract read
In one paragraph

Article in Alzheimer's & dementia (New York, N. Y.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Perfusion fixation in brain banking: a systematic review.Acta neuropathologica communications · 2019
    Pooled it
  4. Article
  5. Review
  6. Digital neuropathology of neurodegenerative disorders: Foundations, research advances, and future directions.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  7. Article
  8. Article
  9. Poly(Ethylene Glycols) to Facilitate Celloidin Removal for Immunohistochemical Studies on Archival Human Brain and Temporal Bone Sections.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2024
    Article
  10. Brain banking in the United States and Europe: Importance, challenges, and future trends.Journal of neuropathology and experimental neurology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. The Role of Clinical Assessment in the Era of Biomarkers.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Essential tremor plus rest tremor: current concepts and controversies.Journal of neural transmission (Vienna, Austria : 1996) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Arenn Faye CarlosNeuropathology Department, Abbiategrasso Brain Bank, Golgi-Cenci Foundation Abbiategrasso, Milan, Italy.
Tino Emanuele PoloniNeuropathology Department, Abbiategrasso Brain Bank, Golgi-Cenci Foundation Abbiategrasso, Milan, Italy.
Valentina MediciNeuropathology Department, Abbiategrasso Brain Bank, Golgi-Cenci Foundation Abbiategrasso, Milan, Italy.
Maia ChikhladzeNeuropathology Department, Abbiategrasso Brain Bank, Golgi-Cenci Foundation Abbiategrasso, Milan, Italy.
Antonio GuaitaNeuropathology Department, Abbiategrasso Brain Bank, Golgi-Cenci Foundation Abbiategrasso, Milan, Italy.
Mauro CeroniUniversity of Pavia, Pavia, Italy.
Fondazione Golgi Cenci · ITUniversity of Pavia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Our current knowledge of the structure, function, and diseases of the brain comes from direct examination of its substance. In the last centuries, only a few elite had managed to retrieve, gather, and preserve the elusive brain for their own research. The resulting brain collections, stored in formalin-filled jars or dried up in cabinets, served anatomical, neuropathological, anthropometric, ideological, and diagnostic purposes. In the 1960s, the first modern brain banks actively collecting and strategically preserving both diseased and healthy brains to be consequently distributed to the scientific community were instituted. In an era where state-of-the-art biochemical "Omic" studies and advanced metabolic and molecular neuroimaging exist, it is now, more than ever, that postmortem brain investigations must be performed. Only through the comparison and integration of postmortem neuropathological and biochemical findings and antemortem data from clinical, neuropsychological neuroimaging, and other biomarker examinations can we truly understand neurological disease mechanisms. Brain banks supplying brain specimens, antemortem information, and postmortem diagnosis are a major benefactor of brain research.

Indexed as

Brain archivingBrain bankBrain bank networkBrain collectionEncephalocentrismHistory of brain bankingHistory of neuroscience

Identifiers

PMID30775417
PMCPMC6365388
OpenAlexW2913224056

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.