ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019
One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Research Progress in Artificial Intelligence-Assisted Preparation of High-Quality Biomaterials.ACS omega · 2026Review
- Polyethylene Glycol Nanofiller for Robust Lyophilization of Graphically Encoded Hydrogel Microparticles.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Tunable Picoliter-Scale Dropicle Formation Using Amphiphilic Microparticles with Patterned Hydrophilic Patches.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Heterogeneous Organohydrogel Toward Automated and Interference-Free Gradient Feeding of Drugs in Cell Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Time-traceable micro-taggants for anti-counterfeiting and secure distribution of food and medicines.Biomicrofluidics · 2024Article
- I-LIFT (image-based laser-induced forward transfer) platform for manipulating encoded microparticles.Biomicrofluidics · 2022Article
- Recent Advances in Polymer Additive Engineering for Diagnostic and Therapeutic Hydrogels.International journal of molecular sciences · 2022Review
- Fish Capsules: A System for High-Throughput Screening of Combinatorial Drugs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Comprehensive strategies of machine-learning-based quantitative structure-activity relationship models.iScience · 2021Review
- Color-Coded Droplets and Microscopic Image Analysis for Multiplexed Antibiotic Susceptibility Testing.Biosensors · 2021Article
- Multi-scale cellular engineering: From molecules to organ-on-a-chip.APL bioengineering · 2020Article
- Microspinning: Local Surface Mixing via Rotation of Magnetic Microparticles for Efficient Small-Volume Bioassays.Micromachines · 2020Article
- Divide and conquer: A perspective on biochips for single-cell and rare-molecule analysis by next-generation sequencing.APL bioengineering · 2019Article
- One-Step Generation of a Drug-Releasing Hydrogel Microarray-On-A-Chip for Large-Scale Sequential Drug Combination Screening.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2019Article
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large-scale screening of sequential drug combinations, wherein the dynamic rewiring of intracellular pathways leads to promising therapeutic effects and improvements in quality of life, is essential for personalized medicine to ensure realistic cost and time requirements and less sample consumption. However, the large-scale screening requires expensive and complicated liquid handling systems for automation and therefore lowers the accessibility to clinicians or biologists, limiting the full potential of sequential drug combinations in clinical applications and academic investigations. Here, a miniaturized platform for high-throughput combinatorial drug screening that is "pipetting-free" and scalable for the screening of sequential drug combinations is presented. The platform uses parallel and bottom-up formation of a heterogeneous drug-releasing hydrogel microarray by self-assembly of drug-laden hydrogel microparticles. This approach eliminates the need for liquid handling systems and time-consuming operation in high-throughput large-scale screening. In addition, the serial replacement of the drug-releasing microarray-on-a-chip facilitates different drug exchange in each and every microwell in a simple and highly parallel manner, supporting scalable implementation of multistep combinatorial screening. The proposed strategy can be applied to various forms of combinatorial drug screening with limited amounts of samples and resources, which will broaden the use of the large-scale screening for precision medicine.
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