Evidence map›Paper›PMID 30775224›Full record

ReviewAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2019

Self-Assembled Nanostructured Lipid Systems: Is There a Link between Structure and Cytotoxicity?

Angel Tan, Linda Hong, Joanne D Du, Ben J Boyd

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

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  18. Temperature-Dependent Reversible Morphological Transformations inThe journal of physical chemistry. B · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Angel TanARC Centre of Excellence in Convergent Bio-Nano Science and Technology Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University, Parkville Campus 381 Royal Parade Parkville VIC 3052 Australia.
Linda HongARC Centre of Excellence in Convergent Bio-Nano Science and Technology Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University, Parkville Campus 381 Royal Parade Parkville VIC 3052 Australia.
Joanne D DuARC Centre of Excellence in Convergent Bio-Nano Science and Technology Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University, Parkville Campus 381 Royal Parade Parkville VIC 3052 Australia.
Ben J BoydARC Centre of Excellence in Convergent Bio-Nano Science and Technology Drug Delivery, Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University, Parkville Campus 381 Royal Parade Parkville VIC 3052 Australia.ORCID https://orcid.org/0000-0001-5434-590X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembly of lipid-based liquid crystalline (LLC) nanoparticles is a formulation art arising from the hydrophilic-lipophilic qualities and the geometric packing of amphiphilic lipid molecules in an aqueous environment. The diversity of commercialized amphiphilic lipids and an increased understanding of the physicochemical factors dictating their membrane curvature has enabled versatile architectural design and engineering of LLC nanoparticles. While these exotic nanostructured materials are hypothesized to form the next generation of smart therapeutics for a broad field of biomedical applications, biological knowledge particularly on the systemic biocompatibility or cytotoxicity of LLC materials remains unclear. Here, an overview on the interactions between LLCs of different internal nanostructures and biological components (including soluble plasma constituents, blood cells, and isolated tissue cell lines) is provided. Factors affecting cell-nanoparticle tolerability such as the type of lipids, type of steric stabilizers, nanoparticle surface charges, and internal nanostructures (or lipid phase behaviors) are elucidated. The mechanisms of cellular uptake and lipid transfer between neighboring membrane domains are also reviewed. A critical analysis of these studies sheds light on future strategies to transform LLC materials into a viable therapeutic entity ideal for internal applications.

Indexed as

cell–nanoparticle interactionsdrug delivery systemsliquid crystalline lipidsself‐assembled nanostructurestissue cytotoxicity

Identifiers

PMID30775224
PMCPMC6364503

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.