Evidence map›Paper›PMID 30775184›Full record

ArticlePeerJ2019

The detailed distribution of T cell subpopulations in immune-stable renal allograft recipients: a single center study.

Quan Zhuang, Bo Peng, Wei Wei, Hang Gong, Meng Yu, Min Yang, Lian Liu, Yingzi Ming

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Quan Zhuang *Transplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0001-5225-9282
Bo Peng *Transplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.
Wei WeiTransplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hang GongTransplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.
Meng YuTransplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.
Min YangTransplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.
Lian LiuTransplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yingzi MingTransplantation Center, The 3rd Xiangya Hospital of Central South University, Changsha, Hunan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost renal allograft recipients reach a stable immune state (neither rejection nor infection) after transplantation. However, the detailed distribution of overall T lymphocyte subsets in the peripheral blood of these immune-stable renal transplant recipients remains unclear. We aim to identify differences between this stable immune state and a healthy immune state.

methodsIn total, 103 recipients underwent renal transplantation from 2012 to 2016 and received regular follow-up in our clinic. A total of 88 of these 103 recipients were enrolled in our study according to the inclusion and exclusion criteria. A total of 47 patients were 1 year post-transplantation, and 41 were 5 years post-transplantation. In addition, 41 healthy volunteers were recruited from our physical examination clinic. Detailed T cell subpopulations from the peripheral blood were assessed via flow cytometry. The parental frequency of each subset was calculated and compared among the diverse groups.

resultsThe demographics and baseline characteristics of every group were analyzed. The frequency of total T cells (CD3+) was decreased in the renal allograft recipients. No difference in the variation of the CD4+, CD8+, and activated (HLA-DR+) T cell subsets was noted among the diverse groups. Regarding T cell receptor (TCR) markers, significant reductions were found in the proportion of γδ T cells and their Vδ2 subset in the renal allograft recipients. The proportions of both CD4+ and CD8+ programmed cell death protein (PD) 1+ T cell subsets were increased in the renal allograft recipients. The CD27+CD28+ T cell proportions in both the CD4+ and CD8+ populations were significantly decreased in the allograft recipients, but the opposite results were found for both CD4+ and CD8+ CD27-CD28- T cells. An increased percentage of CD4+ effector memory T cells and a declined fraction of CD8+ central memory T cells were found in the renal allograft recipients.

conclusionLimited differences in general T cell subsets (CD4+, CD8+, and HLA-DR+) were noted. However, obvious differences between renal allograft recipients and healthy volunteers were identified with TCR, PD1, costimulatory molecules, and memory T cell markers.

Indexed as

Flow cytometryImmune monitoringPD1T cell subsetTCR

Identifiers

PMID30775184
PMCPMC6369828

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