ArticleCase reports in obstetrics and gynecology2019
Squamous Carcinoma of the Neovagina after Male-to-Female Reconstruction Surgery: A Case Report and Review of the Literature.
Article in Case reports in obstetrics and gynecology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Condylomata acuminata in the neovagina and vulva with HPV6/18 infection in a patient with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome after sheares' vaginoplasty: a case report and systematic review.BMC women's health · 2025Pooled it
- The need for screening recommendations after intestinal vaginal replacement: a systematic review of the literature.Pediatric surgery international · 2025Pooled it
- Prevalence and potential implications of HPV infection in transgender women with gender reaffirming genital surgery: a systematic literature review and meta-analysis.Sexually transmitted infections · 2025Pooled it
- Neovaginal Cytologic and Molecular Screening Findings for Human Papillomavirus and Sexually Transmitted Infections Among Transgender Women.Open forum infectious diseases · 2026Article
- Neovaginal squamous cell carcinoma in a transgender woman: Case report, treatment insights, and literature review.Gynecologic oncology reports · 2025Article
- Article
- Neovaginal Human Papilloma Virus-Related Squamous Cell Carcinoma in a Transgender Woman.JAMA network open · 2024Article
- Gender-Affirming Surgery and Cancer: Considerations for Radiation Oncologists for Pelvic Radiation in Transfeminine Patients.International journal of radiation oncology, biology, physics · 2023Review
- Squamous cell carcinoma of the neovagina 47 years after gender-affirming surgery.Urology case reports · 2023Article
- A Case of a Transwoman with Colorectal Cancer after Flap Vaginoplasty.Journal of plastic and reconstructive surgery · 2023Article
- Factors associated with knowledge and vaccination intention for human papillomavirus on trans girls by their main caregiver: A cross-sectional study.Frontiers in immunology · 2023Article
- Anatomical and sexual health considerations among transfeminine individuals who have undergone vaginoplasty: A review.International journal of STD & AIDS · 2022Review
- Development of a mucinous adenocarcinoma on a sigmoid colpoplasty for vaginal agenesis: About a case report and review of the literature.Gynecologic oncology reports · 2021Article
- Cancer screening in the transgender population: a review of current guidelines, best practices, and a proposed care model.Translational andrology and urology · 2020Review
- HPV-Related Neovaginal Squamous Cell Carcinoma Presenting as Lung Metastasis after Male-to-Female Gender Confirmation Surgery.Case reports in oncologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Squamous cell carcinoma (SCC) of the neovagina after genital reconstruction surgery is a rare occurrence with only very few cases published up to the present. We report a case of a 43-year-old transgender woman who developed neovaginal SCC 23 years after vaginoplasty. The patient tested positive for high-risk human papillomavirus (HPV). At the time of diagnosis, radiological investigations revealed already existing lymph node and osseous metastases. The treatment consisted of various cycles of chemotherapy and radiation therapy. Unfortunately, the formation of additional metastases, including cerebral, pulmonary, and hepatic metastases, could not be prevented. After comparing the literature on the topic, we conclude that neovaginal carcinoma often appears years and decades after genital reconstruction surgery. We therefore recommend the continuation of regular clinical follow-up for transgender women after postoperative follow-up is completed. With this approach, potential lesions may be detected at an earlier stage and a better outcome may be achieved. Follow-up should include neovaginal examination and cytological smear testing. At a later age, we recommend additional regular prostate-specific antigen (PSA) testing and digital rectal examination (DRE). Moreover, transgender women are advised to take part in mammography screening starting at the age of 50, especially when additional risk factors are present.
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.