Evidence map›Paper›PMID 30774971›Full record

ArticleBiomaterials research2019

3D printable hyaluronic acid-based hydrogel for its potential application as a bioink in tissue engineering.

Insup Noh, Nahye Kim, Hao Nguyen Tran, Jaehoo Lee, Chibum Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  16. Bioprinting of gelatin-based materials for orthopedic application.Frontiers in bioengineering and biotechnology · 2024
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Insup Noh1Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul, 01811 Republic of Korea.ORCID 0000-0003-0696-7768
Nahye Kim1Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul, 01811 Republic of Korea.
Hao Nguyen Tran1Department of Chemical and Biomolecular Engineering, Seoul National University of Science and Technology, Seoul, 01811 Republic of Korea.
Jaehoo Lee3Department of Mechanical System Design Engineering, Seoul National University of Science and Technology, Seoul, 01811 Republic of Korea.
Chibum Lee3Department of Mechanical System Design Engineering, Seoul National University of Science and Technology, Seoul, 01811 Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAfter recognition of 3D printing and injectable hydrogel as a critical issue in tissue/organ engineering and regenerative medicine society, many hydrogels as bioinks have been developed worldwide by using polymeric biomaterials such as gelatin, alginate, hyaluronic acid and others. Even though some gels have shown good performances in 3D bioprinting, still their performances do not meet the requirements enough to be used as a bioink in tissue engineering.

methodIn this study, a hydrogel consisting of three biocompatible biomaterials such as hyaluronic acid (HA), hydroxyethyl acrylate (HEA) and gelatin-methacryloyl, i.e. HA-g-pHEA-gelatin gel, has been evaluated for its possibility as a bioprinting gel, a bioink. Hydrogel synthesis was obtained by graft polymerization of HEA to HA and then grafting of gelatin- methacryloyl via radical polymerization mechanism. Physical and biological properties of the HA-based hydrogels fabricated with different concentrations of methacrylic anhydride (6 and 8%) for gelatin-methacryloylation have been evaluated such as swelling, rheology, morphology, cell compatibility, and delivery of small molecular dimethyloxalylglycine. Printings of HA-g-pHEA-Gelatin gel and its bioink with bone cell loaded in lattice forms were also evaluated by using home-built multi-material (3D bio-) printing system.

conclusionThe experimental results demonstrated that the HA-g-pHEA-gelatin hydrogel showed both stable rheology properties and excellent biocompatibility, and the gel showed printability in good shape. The bone cells in bioinks of the lattice-printed scaffolds were viable. This study showed HA-g-pHEA-Gelatin gel's potential as a bioink or its tissue engineering applications in injectable and 3D bioprinting forms.

Indexed as

3D bioprintingBiocompatibleGelatinHyaluronic acidTissue engineering

Identifiers

PMID30774971
PMCPMC6364434

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.