Evidence map›Paper›PMID 30774953›Full record

ArticleMultidisciplinary respiratory medicine2019

Predictive factors for exacerbation and re-exacerbation in chronic obstructive pulmonary disease: an extension of the Cox model to analyze data from the Swiss COPD cohort.

Pascal Urwyler, Nebal Abu Hussein, Pierre O Bridevaux, Prashant N Chhajed, Thomas Geiser, Peter Grendelmeier, Ladina Joos Zellweger, Malcolm Kohler, Sabrina Maier, David Miedinger and 4 more

Registry-linked trialAbstract read
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In one paragraph

Article in Multidisciplinary respiratory medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02065921 (Swiss Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 7 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02065921 unknown statusnot on this map

Swiss Chronic Obstructive Pulmonary Disease (COPD) Management Cohort COPD-Management: Eine Klinisch-epidemiologische Verlaufsbeobachtung in Hausarztpraxen

TypeobservationalSponsorProf. Dr. Jörg LeuppiRan2006 to 2025Enrolled265ConditionsChronic Obstructive Pulmonary Disease, COPD Exacerbation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Observational
  4. Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Pascal Urwyler1University Clinic of Medicine, Cantonal Hospital Baselland, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland.
Nebal Abu Hussein2University Hospital Basel, University of Basel, Spitalstrasse 21, 4031 Basel, Switzerland.
Pierre O Bridevaux3Hospital of Valais, University of Geneva, Avenue du Grand-Champsec 80, 1950 Sion, Switzerland.
Prashant N Chhajed1University Clinic of Medicine, Cantonal Hospital Baselland, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland.
Thomas Geiser4University Hospital Bern (Inselspital), University of Bern, Freiburgstrasse 18, 3010 Bern, Switzerland.
Peter Grendelmeier1University Clinic of Medicine, Cantonal Hospital Baselland, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland.
Ladina Joos Zellweger5St. Clara Hospital, University of Basel, Kleinriehenstrasse 30, 4002 Basel, Switzerland.
Malcolm Kohler6University Hospital Zurich, University of Zurich, Rämistrasse 100, 8091 Zürich, Switzerland.
Sabrina Maier1University Clinic of Medicine, Cantonal Hospital Baselland, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland.
David Miedinger1University Clinic of Medicine, Cantonal Hospital Baselland, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland.
Michael Tamm2University Hospital Basel, University of Basel, Spitalstrasse 21, 4031 Basel, Switzerland.
Robert ThurnheerCantonal Hospital of Muensterlingen, Spitalcampus 1, 8596 Münsterlingen, Switzerland.
Thomas Dieterle1University Clinic of Medicine, Cantonal Hospital Baselland, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland.
Joerg D Leuppi1University Clinic of Medicine, Cantonal Hospital Baselland, University of Basel, Rheinstrasse 26, 4410 Liestal, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Swiss COPD cohort was established in 2006 to collect data in a primary care setting. The objective of this study was to evaluate possible predictive factors for exacerbation and re-exacerbation.

methodsIn order to predict exacerbation until the next visit based on the knowledge of exacerbation since the last visit, a multistate model described by Therneau and Grambsch was performed.

resultsData of 1,247 patients (60.4% males, 46.6% current smokers) were analyzed, 268 (21.5%) did not fulfill spirometric diagnostic criteria for COPD. Data of 748 patients (63% males, 44.1% current smokers) were available for model analysis. In order to predict exacerbation an extended Cox Model was performed. Mean FEV

conclusionOur data confirmed well-established risk factors for exacerbations whilst analyzing their predictive association with exacerbation and re-exacerbation. This study confirmed the importance of spirometry in primary care, not only for diagnosis but also as a risk evaluation for possible future exacerbations.

trial registrationOur study got approval by local ethical committee in 2006 (EK Nr. 170/06) and was registered retrospectively on ClinicalTrials.gov (NCT02065921, 19

Indexed as

COPDExacerbationPrimary health careRe-exacerbationRisk factors

Identifiers

PMID30774953
PMCPMC6364405

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.