ArticleChemical science2019
Oxidative steps during the biosynthesis of squalestatin S1.
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- BioprospectingFrontiers in fungal biology · 2021Pooled it
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- A high-quality genome assembly and annotation of Thielaviopsis punctulata DSM102798.Scientific data · 2024Article
- Genome Characteristics of the Endophytic FungusJournal of fungi (Basel, Switzerland) · 2024Article
- Synthetic Biology Tools for EngineeringJournal of fungi (Basel, Switzerland) · 2024Review
- Engineered and total biosynthesis of fungal specialized metabolites.Nature reviews. Chemistry · 2024Review
- Comparative genome analysis of the freshwater fungus Filosporella fistucella indicates potential for plant-litter degradation at cold temperatures.G3 (Bethesda, Md.) · 2023Article
- Insights into the genomic architecture of a newly discovered endophyticFrontiers in microbiology · 2023Article
- Branching and converging pathways in fungal natural product biosynthesis.Fungal biology and biotechnology · 2022Review
- In silico analyses of maleidride biosynthetic gene clusters.Fungal biology and biotechnology · 2022Article
- Secondary metabolite biosynthetic diversity in the fungal familyStudies in mycology · 2021Article
- Article
- The sporothriolides. A new biosynthetic family of fungal secondary metabolites.Chemical science · 2020Article
- Uncovering biosynthetic relationships between antifungal nonadrides and octadrides.Chemical science · 2020Article
- Reengineering the programming of a functional domain of an iterative highly reducing polyketide synthase.RSC advances · 2020Article
- Molecular basis of methylation and chain-length programming in a fungal iterative highly reducing polyketide synthase.Chemical science · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The squalestatins are a class of highly complex fungal metabolites which are potent inhibitors of squalene synthase with potential use in the control of cholesterol biosynthesis. Little is known of the chemical steps involved in the construction of the 4,8-dioxa-bicyclo[3.2.1]octane core. Here, using a combination of directed gene knockout and heterologous expression experiments, we show that two putative non-heme-iron-dependent enzymes appear to catalyse a remarkable series of six consecutive oxidations which set up the bioactive core of the squalestatins. This is followed by the action of an unusual copper-dependent oxygenase which introduces a hydroxyl required for later acetylation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.