Evidence map›Paper›PMID 30774914›Full record

ArticleChemical science2019

Activatable cell-biomaterial interfacing with photo-caged peptides.

Yiyang Lin, Manuel M Mazo, Stacey C Skaalure, Michael R Thomas, Simon R Schultz, Molly M Stevens

Open access · diamondAbstract read
In one paragraph

Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Optical control of purinergic signaling.Purinergic signalling · 2021
    Review
  6. Review
  7. Article
  8. Molecular Regulators of Cellular Mechanoadaptation at Cell-Material Interfaces.Frontiers in bioengineering and biotechnology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Yiyang LinDepartment of Materials , Department of Bioengineering and Institute for Biomedical Engineering , Imperial College London , Exhibition Road , London SW7 2AZ , UK . Email: m.stevens@imperial.ac.uk.ORCID 0000-0003-2017-190X
Manuel M MazoDepartment of Materials , Department of Bioengineering and Institute for Biomedical Engineering , Imperial College London , Exhibition Road , London SW7 2AZ , UK . Email: m.stevens@imperial.ac.uk.
Stacey C SkaalureDepartment of Materials , Department of Bioengineering and Institute for Biomedical Engineering , Imperial College London , Exhibition Road , London SW7 2AZ , UK . Email: m.stevens@imperial.ac.uk.ORCID 0000-0001-5746-0575
Michael R ThomasDepartment of Materials , Department of Bioengineering and Institute for Biomedical Engineering , Imperial College London , Exhibition Road , London SW7 2AZ , UK . Email: m.stevens@imperial.ac.uk.ORCID 0000-0001-7795-9648
Simon R SchultzDepartment of Bioengineering and Centre for Neurotechnology , Imperial College London , London SW7 2AZ , UK.
Molly M StevensDepartment of Materials , Department of Bioengineering and Institute for Biomedical Engineering , Imperial College London , Exhibition Road , London SW7 2AZ , UK . Email: m.stevens@imperial.ac.uk.ORCID 0000-0002-7335-266X
Imperial College London · GBBioengineering Center · RU

Funding

European Research Council 616417Wellcome Trust 098411
6 · The paper itself

Abstract

Spatio-temporally tailoring cell-material interactions is essential for developing smart delivery systems and intelligent biointerfaces. Here we report new photo-activatable cell-material interfacing systems that trigger cellular uptake of various cargoes and cell adhesion towards surfaces. To achieve this, we designed a novel photo-caged peptide which undergoes a structural transition from an antifouling ligand to a cell-penetrating peptide upon photo-irradiation. When the peptide is conjugated to ligands of interest, we demonstrate the photo-activated cellular uptake of a wide range of cargoes, including small fluorophores, proteins, inorganic (

Identifiers

PMID30774914
PMCPMC6349021
OpenAlexW2901189668

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.