ArticleChemical science2019
Ni-catalyzed migratory fluoro-alkenylation of unactivated alkyl bromides with
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Cross-Electrophile Coupling: Principles, Methods, and Applications in Synthesis.Chemical reviews · 2024Review
- Ni-catalysed remote C(spNature reviews. Chemistry · 2024Review
- Regio-, stereo-, and enantioselective ipso- and migratory defluorinative olefin cross-coupling to access highly functionalized monofluoroalkenes.Nature communications · 2024Article
- Stereodivergent Palladium-Catalyzed C-F Bond Functionalization ofOrganic letters · 2024Article
- Kinetically-Controlled Ni-Catalyzed Direct Carboxylation of Unactivated Secondary Alkyl Bromides without Chain Walking.Journal of the American Chemical Society · 2024Article
- Ni/Photoredox-Catalyzed C(spJournal of the American Chemical Society · 2022Article
- Synthesis of bioactive fluoropyrrolidinesChemical science · 2022Article
- γ-Selective C(spNature communications · 2021Article
- Nickel-catalysed migratory hydroalkynylation and enantioselective hydroalkynylation of olefins with bromoalkynes.Nature communications · 2021Article
- NiH-catalyzed asymmetric hydroarylation of N-acyl enamines to chiral benzylamines.Nature communications · 2021Article
- Arylation ofChemical science · 2020Article
- Palladium-Catalyzed Cross-Coupling ofMolecules (Basel, Switzerland) · 2020Article
- Migratory functionalization of unactivated alkyl bromides for construction of all-carbon quaternary centers via transposed tert-C-radicals.Nature communications · 2020Article
- Ru-catalyzed isomerization of ω-alkenylboronates towards stereoselective synthesis of vinylboronates with subsequentChemical science · 2020Article
- Recent Advances in Transition Metal-Catalyzed Functionalization ofIsrael journal of chemistry · 2020Article
- Nickel-Catalyzed Arylboration of Alkenylarenes: Synthesis of Boron-Substituted Quaternary Carbons and Regiodivergent Reactions.Angewandte Chemie (International ed. in English) · 2019Article
- Selective C-F bond carboxylation ofChemical science · 2019Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe a nickel-catalyzed highly regio- and stereoselective migratory fluoro-alkenylation of unactivated alkyl bromides. A unique catalytic cycle merging alkyl nickel chain-walking and defluorinative coupling enables the introduction of a broad array of fluoroalkenyl moieties into carbon chains. Control experiments with other halogenated alkenes demonstrated the essential role of fluorine atoms in this reaction. Notably, the reaction proceeds under mild conditions and allows for the synthesis of a variety of valuable monofluoroalkenes.
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Registered trials
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