ArticleChemical science2019
Visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using O
Article in Chemical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 146 citations in OpenAlex.
- Comprehensive perspectives of metal and metal-free C-H activation approaches in pyrimidines and related heteroarenes: scope, mechanistic insights, and synthetic utility.RSC advances · 2025Review
- Monofluoromethyl Radical Mediated Halogen-Atom Transfer.Journal of the American Chemical Society · 2025Article
- Late-Stage Heteroarene Alkylation via Minisci Reaction with Gaseous Alkanes Enabled by Hydrogen Atom Transfer in Flow.ACS central science · 2025Article
- Photocatalytic Decarboxylative Minisci Reaction Catalyzed by Palladium-Loaded Gallium Nitride.Precision chemistry · 2023Article
- Late-Stage C-H Functionalization of Azines.Chemical reviews · 2023Review
- Photoinduced Halogen-Atom Transfer byJournal of the American Chemical Society · 2023Article
- PeptideACS central science · 2022Article
- Heteroarylation of unactivated C-H bonds suitable for late-stage functionalization.Chemical science · 2022Article
- General electrochemical Minisci alkylation ofChemical science · 2022Article
- Oxidase-Type C-H/C-H Coupling Using an Isoquinoline-Derived Organic Photocatalyst.Angewandte Chemie (International ed. in English) · 2022Article
- Article
- Generation of Alkyl Radicals: From the Tyranny of Tin to the Photon Democracy.Chemical reviews · 2020Article
- Ketones and aldehydes as alkyl radical equivalents for C─H functionalization of heteroarenes.Science advances · 2019Article
- Article
Corrections and comments
- Erratum issued
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herein, we report a protocol for direct visible-light-mediated Minisci C-H alkylation of heteroarenes with unactivated alkyl halides using molecular oxygen as an oxidant at room temperature. This mild protocol is compatible with a wide array of sensitive functional groups and has a broad substrate scope. Notably, functionalization of (iso)quinolines, pyridines, phenanthrolines, quinazoline, and other heterocyclic compounds with unactivated primary, secondary, and tertiary alkyl halides proceeds smoothly under the standard conditions. The robustness of this protocol is further demonstrated by the late-stage functionalization of complex nitrogen-containing natural products and drugs.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.