ArticleGastroenterology and hepatology from bed to bench2018
SRC and TP53 play critical role in low-grade dysplasia colorectal mucosa transformation into cancer.
Article in Gastroenterology and hepatology from bed to bench, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Evaluation of Skin Response After Erbium:Yttrium- Aluminum-Garnet Laser Irradiation: A Network Analysis Approach.Journal of lasers in medical sciences · 2019Article
- Predication of hub target genes of differentially expressed microRNAs contributing toGastroenterology and hepatology from bed to bench · 2019Article
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Authors and funding
5 authors.
Funding
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Abstract
aimDetermination of crucial genes that are involved in onset and progress of dysplasia of colorectal mucosa is the aim of this study.
backgroundManagement of dysplasia as one of the risk factors of colon cancer is very challenging. Molecular studies could be helpful in this matter. Here, the transcriptome profile of low-grade dysplasia in colon tissue in comparison with normal one is studied by protein-protein interaction (PPI) network analysis.
methodsFor detecting differentially expressed genes (DEGs) of dysplasia lesion, the data was downloaded from the gene chip GSE31106, platform GPL1261, GSM770092-94 as normal colorectal mucosa group and GSM770098-100 as low-grade dysplasia colorectal mucosa from the Gene Expression Omnibus database (GEO). The expression profile is evaluated by GEO2R and a network of DEGs is constructed and analyzed by Cytoscape algorithms.
resultsThe findings indicate that a PPI network analysis of 113 DEGs is consist of 8 nodes that 6 of them are common with inflammation state. Only SRC and TP53 were recognized as the specific makers for dysplasia. In this respect, a subnetwork of these two genes introduce a panel of 8 nodes consist of HRAS, MYC, PIK3CA, PIK3CB, PIK3CD, PIK3CG, SRC, and TP53.
conclusionIt can be concluded that SRC and TP53 may play prominent role in dysplasia pathogenicity after running validation tests.
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30774815PMC6347985What OpenQuestion holds
Registered trials
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