ArticleIranian journal of pathology2018
The Effect of Cadmium on Apoptotic Genes mRNA Expression of Bax and Bcl-2 in Small Intestine of Rats.
Article in Iranian journal of pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 20 citations in OpenAlex.
- Evaluation of the divergent effects of pyrethroid- and D-allethrin-based coil fumes in male Wistar rats.Environmental analysis, health and toxicology · 2025Article
- Epigallocatechin gallate attenuated high glucose-induced pancreatic beta cell dysfunction by modulating DRP1-mediated mitochondrial apoptosis pathways.Scientific reports · 2024Article
- Zinc Chloride Can Mitigate the Alterations in Metallothionein and Some Apoptotic Proteins Induced by Cadmium Chloride in Mice Hepatocytes: A Histological and Immunohistochemical Study.Journal of toxicology · 2023Article
- TRAF2/ASK1/JNK Signaling Pathway Is Involved in the Lung Apoptosis of Swine Induced by Cadmium Exposure.Biological trace element research · 2022Article
- The protective role of Coenzyme Q10 in metallothionein-3 expression in liver and kidney upon rats' exposure to lead acetate.Molecular biology reports · 2021Article
- The role of long noncoding RNA SNHG7 in human cancers (Review).Molecular and clinical oncology · 2020Review
- Protective effects of vitamin E on cadmium-induced apoptosis in rat testes.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- Mechanism of cadmium poisoning on testicular injury in mice.Oncology letters · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
objectiveCadmium is a potent toxicant and carcinogenic substance for human and experimental animals. The evidences indicate that cadmium induces aberrant gene expression, inhibition of DNA damage repair, and apoptosis. In this study, we investigated the effects of IP (intraperitoneal) injection of cadmium on mRNA levels expression of Bcl-2 and Bax genes in rat small intestine.
methods28 male Wistar rats weighing 200 to 250 grams were randomly assigned into 4 groups. Group 1 received saline while the animals in groups 2-4 were injected cadmium (1, 2 and 4 mg/kg) for 15 successive days. One day after the last injection, the small intestine was dissected and the mRNA levels expression of Bax and Bcl-2 genes was evaluated using Real Time PCR technique.
resultsCadmium increased the mRNA levels of Bax gene compared to the control group at 2 and 4 mg/kg (
conclusionThese results showed Cadmium exposure induced cell apoptosis by increasing Bax/Bcl-2 ratio expression.
Indexed as
Identifiers
30774679PMC6358564W2888874555What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.