ArticleFrontiers in human neuroscience2019
Atypical Flexibility in Dynamic Functional Connectivity Quantifies the Severity in Autism Spectrum Disorder.
Article in Frontiers in human neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 118 citations in OpenAlex.
- Neuroplastic Mechanisms of Acupuncture in Post-Stroke Motor Recovery: A Randomized Multimodal MRI Trial.CNS neuroscience & therapeutics · 2026Trial
- Autism Spectrum Disorder (ASD) Through the Lens of Hidden Markov Models (HMMs) Applied to Resting-State fMRI (rs-fMRI): A Systematic Review and Meta-analysis.Journal of autism and developmental disorders · 2026Article
- Spatiotemporal brain-state dynamics delineate executive function subtypes in school-aged autism: evidence from co-activation patterns and a four-year follow-up.Molecular autism · 2026Article
- Dynamic Resting-State Network Markers of Disruptive Behavior Problems in Youth.Biological psychiatry global open science · 2026Article
- Beyond networks: Toward adaptive models of biological complexity.Physics of life reviews · 2026Review
- Network flexibility facilitates treatment-induced recovery in post-stroke aphasia.Brain communications · 2026Article
- Dynamic structure-function coupling in macroscale neonatal brain networks.Communications biology · 2025Article
- Sex Similarities and Differences in Brain Dynamic Functional Connectivity Among Individuals With and Without Autism Spectrum Disorders.Human brain mapping · 2025Article
- Linking Connectivity Dynamics to Symptom Severity and Cognitive Abilities in Children with Autism Spectrum Disorder: An FNIRS Study.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Neurobiological and Behavioral Heterogeneity in Adolescents with Autism Spectrum Disorder.Brain sciences · 2025Review
- Transformative Effects of Mindfulness Meditation Training on the Dynamic Reconfiguration of Executive and Default Mode Networks in Internet Gaming Disorder.Biological psychiatry global open science · 2025Article
- Analysis of dynamic network reconfiguration in HIV patients with cognitive impairment based multilayer network.Scientific reports · 2025Article
- Disentangling the Switching Behavior in Functional Connectivity Dynamics in Autism Spectrum Disorder: Insights from Developmental Cohort Analysis and Molecular-Cellular Associations.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- DySCo: A general framework for dynamic functional connectivity.PLoS computational biology · 2025Article
- A lightweight, end-to-end explainable, and generalized attention-based graph neural network model trained on high-order spatiotemporal organization of dynamic functional connectivity to classify autistics from typically developing.Network neuroscience (Cambridge, Mass.) · 2025Article
- Dynamic reconfiguration of brain functional networks in world class gymnasts: a resting-state functional MRI study.Brain communications · 2025Article
- Sex differences in the flexibility of dynamic network reconfiguration of autism spectrum disorder based on multilayer network.Brain imaging and behavior · 2024Article
- Characterization of the temporal stability of ToM and pain functional brain networks carry distinct developmental signatures during naturalistic viewing.Scientific reports · 2024Article
- Aberrant Flexibility of Dynamic Brain Network in Patients with Autism Spectrum Disorder.Bioengineering (Basel, Switzerland) · 2024Article
- Dynamic multilayer functional connectivity detects preclinical and clinical Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resting-state functional connectivity (FC) analyses have shown atypical connectivity in autism spectrum disorder (ASD) as compared to typically developing (TD). However, this view emerges from investigating static FC overlooking the whole brain transient connectivity patterns. In our study, we investigated how age and disease influence the dynamic changes in functional connectivity of TD and ASD. We used resting-state functional magnetic resonance imaging (rs-fMRI) data stratified into three cohorts: children (7-11 years), adolescents (12-17 years), and adults (18+ years) for the analysis. The dynamic variability in the connection strength and the modular organization in terms of measures such as flexiblity, cohesion strength, and disjointness were explored for each subject to characterize the differences between ASD and TD. In ASD, we observed significantly higher inter-subject dynamic variability in connection strength as compared to TD. This hyper-variability relates to the symptom severity in ASD. We also found that whole-brain flexibility correlates with static modularity only in TD. Further, we observed a core-periphery organization in the resting-state, with Sensorimotor and Visual regions in the rigid core; and DMN and attention areas in the flexible periphery. TD also develops a more cohesive organization of sensorimotor areas. However, in ASD we found a strong positive correlation of symptom severity with flexibility of rigid areas and with disjointness of sensorimotor areas. The regions of the brain showing high predictive power of symptom severity were distributed across the cortex, with stronger bearings in the frontal, motor, and occipital cortices. Our study demonstrates that the dynamic framework best characterizes the variability in ASD.
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