ReviewOpen access rheumatology : research and reviews2019
Enthesitis-related arthritis: current perspectives.
Review in Open access rheumatology : research and reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Serum tRF-4575 may regulate osteoclast differentiation and serve as a promising biomarker for enthesitis-related arthritis diagnosis.Genes & diseases · 2026Article
- Juvenile vs. Adult-Onset Spondyloarthritis: Uncovering Similarities and Differences.Archives of rheumatology · 2026Article
- Atraumatic atlantoaxial subluxation in pediatric enthesitis-related juvenile idiopathic arthritis: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Hip Involvement in Pediatric Scurvy: Early Magnetic Imaging Signs.Children (Basel, Switzerland) · 2025Article
- Clinical Impact of HLA-B27 on Juvenile Idiopathic Arthritis: Eighteen Years of Follow-up in the Population-Based Nordic Juvenile Idiopathic Arthritis Cohort.ACR open rheumatology · 2025Article
- The epidemiology and biologics treatment patterns of juvenile idiopathic arthritis in Taiwan- an 8-year follow-up.Frontiers in immunology · 2025Observational
- Presentation of enthesitis-related arthritis and juvenile-onset spondyloarthritis: a cross-sectional study in a pediatric and adult clinic.Advances in rheumatology (London, England) · 2024Article
- Application of the new classification proposal for juvenile idiopathic arthritis of the pediatric rheumatology international trials organization in a group of Mexican patients.Frontiers in pediatrics · 2024Article
- Advances in the Diagnosis and Treatment of Enthesitis-Related Arthritis.Children (Basel, Switzerland) · 2023Review
- Revising diagnosis of juvenile idiopathic arthritis in adults: a single-center retrospective study.Rheumatology international · 2023Article
- Risk of Psychiatric Disorders in Juvenile Idiopathic Arthritis: Population- and Sibling-Controlled Cohort and Cross-Sectional Analyses.ACR open rheumatology · 2023Article
- Enthesitis-related arthritis: the clinical characteristics and factors related to MRI remission of sacroiliitis.BMC musculoskeletal disorders · 2022Article
- Identification of Novel Loci Shared by Juvenile Idiopathic Arthritis Subtypes Through Integrative Genetic Analysis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Spondyloarthritides: Theories and beyond.Frontiers in pediatrics · 2022Review
- B Cells on the Stage of Inflammation in Juvenile Idiopathic Arthritis: Leading or Supporting Actors in Disease Pathogenesis?Frontiers in medicine · 2022Review
- Juvenile spondyloartropathies.European journal of rheumatology · 2022Article
- Juvenile idiopathic arthritis: from aetiopathogenesis to therapeutic approaches.Pediatric rheumatology online journal · 2021Review
- Enthesitis Related Arthritis in a Longitudinal Southeast Asian Registry: High Prevalence of HLA-B27, Different Sacroiliitis Risk Factors and Less Common Drug-Free Remission.Journal of clinical medicine · 2021Article
- Immunopathophysiology of Juvenile Spondyloarthritis (jSpA): The "Out of the Box" View on Epigenetics, Neuroendocrine Pathways and Role of the Macrophage Migration Inhibitory Factor (MIF).Frontiers in medicine · 2021Review
- Capturing the enthesitis related arthritis contemporary profile of Caucasian patients in the era of biologics.Rheumatology international · 2020Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this narrative review, we overview the recent literature on enthesitis-related arthritis (ERA). For the purpose of our review, we searched Scopus for recent articles on this subject from 2013 onward, including some classic older articles for perspective. ERA is a juvenile idiopathic arthritis (JIA) subtype more common in males, associated in a majority with human leucocyte antigen B27. Such children generally present with asymmetric oligoarthritis or polyarthritis, predominantly of lower limb joints, associated with enthesitis or sacroiliitis. While diagnosis remains clinical, ultrasound is being increasingly used to detect subclinical enthesitis and for guiding entheseal site injections. Spine MRI can help detect sacroiliitis, inflammatory spinal changes, and pelvic sites of enthesitis in such patients. The recent juvenile spondyloarthropathy disease activity index recognizes the key clinical features of ERA, viz enthesitis and inflammatory back pain, which other disease activity indices used in JIA did not include. Management includes NSAIDs with physical therapy. Conventional disease-modifying agents like sulfasalazine and methotrexate may be used to minimize duration of NSAID use and in those with high inflammatory burden. In patients refractory to these drugs, biologics such as antitumor necrosis factor alpha agents have proven useful, based on evidences from randomized controlled trials and retrospective registry analyses. Factors predicting a poorer outcome in such children include hip or ankle involvement or restricted spinal mobility. Considering that children with ERA have overall poorer long-term outcomes than other subtypes of JIA, there is a need to further optimize therapeutic strategies for such patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.