ArticleInternational journal of nanomedicine2019
An efficient and long-acting local anesthetic: ropivacaine-loaded lipid-polymer hybrid nanoparticles for the control of pain.
Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Effect of nerve block combined with superficial general anaesthesia on anaesthetic dosage and anaesthetic awakening in paediatric surgery.BMC anesthesiology · 2025Trial
- Analgesic effects of different concentrations of ropivacaine in transversalis fascia plane block during laparotomy.BMC anesthesiology · 2022Trial
- Effectiveness of ropivacaine-loaded ReproGel drug delivery system in a rat model of postoperative pain.The Korean journal of pain · 2026Article
- Synephrine potentiates lidocaine-induced cutaneous analgesia via α-adrenergic receptors in male rats.Physiological reports · 2026Article
- Topical and transdermal lipid-polymer hybrid nanoparticles (LPN): an integration in advancing dermatological treatments.Drug delivery and translational research · 2025Review
- Advances in the use of local anesthetic extended-release systems in pain management.Drug delivery · 2024Review
- Sustained release local anesthetics for pain management: relevance and formulation approaches.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Lipid-Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery.Journal of functional biomaterials · 2023Review
- Recent Research Advances in Nano-Based Drug Delivery Systems for Local Anesthetics.Drug design, development and therapy · 2023Review
- Biomembrane-Based Nanostructure- and Microstructure-Loaded Hydrogels for Promoting Chronic Wound Healing.International journal of nanomedicine · 2023Review
- Pharmacological Evaluation of the Anesthetic and Analgesic Potential of Injection Harsha 22: A Novel Polyherbal Local Anesthetic Formulation Intended for Parenteral Administration in Wistar Albino Rats.Journal of experimental pharmacology · 2023Article
- Emerging Anesthetic Nanomedicines: Current State and Challenges.International journal of nanomedicine · 2023Review
- Combination anesthetic therapy: co-delivery of ropivacaine and meloxicam using transcriptional transactivator peptide modified nanostructured lipid carriersDrug delivery · 2022Article
- Design of hydroxy-α-sanshool loaded nanostructured lipid carriers as a potential local anesthetic.Drug delivery · 2022Article
- Article
- Enhanced Antitumor Activity of Lidocaine Nanoparticles Encapsulated by a Self-Assembling Peptide.Frontiers in pharmacology · 2022Article
- Topical anesthetic and pain relief using penetration enhancer and transcriptional transactivator peptide multi-decorated nanostructured lipid carriers.Drug delivery · 2021Article
- Comparative evaluation of ropivacaine and lidocaine as dental pulp anaesthesia.Bioinformation · 2021Article
- Article
- Injectable Lipid-Based Depot Formulations: Where Do We Stand?Pharmaceutics · 2020Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeLocal anesthetics are used clinically for the control of pain following operation (including gastrointestinal surgery) or for the management of other acute and chronic pain. This study aimed to develop a kind of lipid-polymer hybrid nanoparticles (LPNs), which were constructed using poly(ethylene glycol)-distearoylphosphatidylethanolamine (PEG-DSPE) as the hydrophilic lipid shell and poly-ε-caprolactone (PCL) as the hydrophobic polymeric core.
methodsRopivacaine (RPV) was entrapped in the LPNs (RPV-LPNs) and the physicochemical and biochemical properties such as size, zeta potential, drug release, and cytotoxicity were studied. The long-lasting effects and safety aspects of the LPNs were evaluated in vitro and in vivo.
resultsThe particle size and zeta potential of RPV-LPNs were 112.3±2.6 nm and -33.2±3.2 mV, with an entrapment efficiency (EE) of 90.2%±3.7%. Ex vivo permeation efficiency of LPNs was better than the drug solution. The RPV-LPNs exhibited a long-lasting in vivo anesthesia effect in both rats and mice.
conclusionConsidering the low cytotoxicity, the LPNs prepared here could be used as an efficient local anesthetic for the control of pain.
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Registered trials
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