Evidence map›Paper›PMID 30774339›Full record

ArticleInternational journal of nanomedicine2019

High loads of nano-hydroxyapatite/graphene nanoribbon composites guided bone regeneration using an osteoporotic animal model.

Francilio Carvalho Oliveira, Jancineide Oliveira Carvalho, Suziete Batista Soares Gusmão, Licia de Sousa Gonçalves, Liana Martha Soares Mendes, Sérgio Antonio Pereira Freitas, Gustavo Oliveira de Meira Gusmão, Bartolomeu Cruz Viana, Fernanda Roberta Marciano, Anderson Oliveira Lobo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francilio Carvalho OliveiraInstitute of Science and Technology, Brasil University, Itaquera 08230-030, São Paulo, Brazil, lobo@ufpi.edu.br.
Jancineide Oliveira CarvalhoInstitute of Science and Technology, Brasil University, Itaquera 08230-030, São Paulo, Brazil, lobo@ufpi.edu.br.
Suziete Batista Soares GusmãoLIMAV-Interdisciplinary Laboratory for Advanced Materials, Materials Science and Engineering Graduate Program, Technological Center, UFPI-Federal University of Piauí, Teresina 64049-550, Piaui, Brazil, lobo@ufpi.edu.br.
Licia de Sousa GonçalvesUniversity Center for Health, Humanities and Technology of Piauí, (UNINOVAFAPI), Teresina, Piauí, Brazil.
Liana Martha Soares MendesDepartment of Specialized Medicine, Federal University of Piauí, Teresina 64017-775, Piaui, Brazil.
Sérgio Antonio Pereira FreitasUniversity Center for Health, Humanities and Technology of Piauí, (UNINOVAFAPI), Teresina, Piauí, Brazil.
Gustavo Oliveira de Meira GusmãoDepartment of Physics, State University of Piaui, Teresina 64002-150, Piaui, Brazil.
Bartolomeu Cruz VianaLIMAV-Interdisciplinary Laboratory for Advanced Materials, Materials Science and Engineering Graduate Program, Technological Center, UFPI-Federal University of Piauí, Teresina 64049-550, Piaui, Brazil, lobo@ufpi.edu.br.
Fernanda Roberta MarcianoInstitute of Science and Technology, Brasil University, Itaquera 08230-030, São Paulo, Brazil, lobo@ufpi.edu.br.
Anderson Oliveira LoboInstitute of Science and Technology, Brasil University, Itaquera 08230-030, São Paulo, Brazil, lobo@ufpi.edu.br.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIt has been difficult to find bioactive compounds that can optimize bone repair therapy and adequate osseointegration for people with osteoporosis. The nano-hydroxyapatite (nHAp)/carbon nanotubes with graphene oxides, termed graphene nanoribbons (GNR) composites have emerged as promising materials/scaffolds for bone regeneration due to their bioactivity and osseointegration properties. Herein, we evaluated the action of nHAp/GNR composites (nHAp/GNR) to promote bone regeneration using an osteoporotic model. MATERIALS AND

methodsFirst, three different nHAp/GNR (1, 2, and 3 wt% of GNR) were produced and characterized. For in vivo analyses, 36 Wistar rats (var. albinus, weighing 250-300 g, Comissão de Ética no Uso de Animais [CEUA] n.002/17) were used. Prior to implantation, osteoporosis was induced by oophorectomy in female rats. After 45 days, a tibial fracture was inflicted using a 3.0-mm Quest trephine drill. Then, the animals were separated into six sample groups at two different time periods of 21 and 45 days. The lesions were filled with 3 mg of one of the above samples using a curette. After 21 or 45 days of implantation, the animals were euthanized for analysis. Histological, biochemical, and radiographic analyses (DIGORA method) were performed. The data were evaluated through ANOVA, Tukey test, and Kolmogorov-Smirnov test with statistical significance at

resultsBoth nHAp and GNR exhibited osteoconductive activity. However, the nHAp/GNR exhibited regenerative activity proportional to their concentration, following the order of 3% >2% >1% wt.

conclusionTherefore, it can be inferred that all analyzed nanoparticles promoted bone regeneration in osteoporotic rats independent of analyzed time.

Indexed as

Bone RegenerationAlkaline PhosphataseAnimalsDisease Models, AnimalDurapatiteFemaleGraphiteNanotubes, CarbonOsteoporosisOvariectomyRats, WistarTibiaTissue ScaffoldsAlkaline PhosphataseDurapatiteGraphiteNanotubes, Carbonbiomaterialscarbon nanotubescompositesgraphenein vivonano-hydroxyapatiteosteoporosis

Identifiers

PMID30774339
PMCPMC6361224

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.