SynthesisWorld journal of gastroenterology2019
Fatigue in children and adolescents with inflammatory bowel disease.
Synthesis in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Symptom cluster profiles in adolescents with inflammatory bowel disease: Cross-sectional study using ImproveCareNow data.Journal of pediatric gastroenterology and nutrition · 2026Article
- Fatigue in pediatric inflammatory bowel disease: Explained by transdiagnostic and disease-focused factors.Journal of pediatric gastroenterology and nutrition · 2026Article
- Associated factors and assessment of clinical symptoms including fatigue, insomnia, and gastrointestinal discomfort of chronic fatigue syndrome: a cross-sectional case-control study.Journal of translational medicine · 2026Article
- PHARMACOLOGICAL TREATMENTS FOR FATIGUE IN INFLAMMATORY BOWEL DISEASE PATIENTS: AN INTEGRATIVE REVIEW.Arquivos de gastroenterologia · 2026Review
- Fatigue in inflammatory bowel disease: Prevalence, risk factors, assessment, outcomes, and management.World journal of gastrointestinal pathophysiology · 2025Review
- Article
- Explorative study on the value of hepcidin in predicting iron non-responsiveness in paediatric inflammatory bowel disease.Pediatric research · 2025Article
- Challenges in the Management of Inflammatory Bowel Disease in Children: A Narrative Review.Clinical and experimental gastroenterology · 2025Review
- Greater Fatigue and Reduced Neurocognitive Speed With Symptomatic Crohn's Disease.Crohn's & colitis 360 · 2025Article
- Change from originator infliximab to biosimilar does not affect 1-year outcome in children with inflammatory bowel disease.JPGN reports · 2024Article
- Considerations in Paediatric and Adolescent Inflammatory Bowel Disease.Journal of Crohn's & colitis · 2024Review
- Fatigue in children and adolescents with inflammatory bowel disease: a cross-sectional study.Frontiers in pediatrics · 2024Article
- Article
- Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood.Diagnostics (Basel, Switzerland) · 2023Review
- Impact of Female Gender in Inflammatory Bowel Diseases: A Narrative Review.Journal of personalized medicine · 2023Review
- Approach to the child with fatigue: A focus for the general pediatrician.Frontiers in pediatrics · 2022Article
- Internet and smartphone-based ecological momentary assessment and personalized advice (PROfeel) in adolescents with chronic conditions: A feasibility study.Internet interventions · 2021Article
- Role of parents in fatigue of children with a chronic disease: a cross-sectional study.BMJ paediatrics open · 2021Article
- Fatigue among children with a chronic disease: a cross-sectional study.BMJ paediatrics open · 2021Article
- Quality of Life in Children and Adolescents with Inflammatory Bowel Disease: Impact and Predictive Factors.Pediatric gastroenterology, hepatology & nutrition · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo identify factors other than active disease and anemia that contribute to fatigue in pediatric inflammatory bowel disease (IBD).
methodsWe performed an electronic search in Medline and EMBASE from their inception to May 2017 using the search term "fatigue" or the related keywords "physical impairment" and "inflammatory bowel disease" with the filter "child" (age 0-18 years). Cross-sectional and case-control studies were included. We restricted our search to studies published in English. We used the PRISMA checklist and flow diagram. Duplicate articles were manually deleted in End Note. To identify further relevant studies, we checked the reference lists of the selected articles.
resultsWe identified 149 papers, of which 19 were retrieved for full text review. Eleven studies were subsequently excluded because fatigue was not evaluated as an outcome measure. Eight papers focused on the desired topic and were discussed in the final analysis. A lack of uniformity of outcome measures made the pooling of data impossible. In all but one study, questionnaires were used to evaluate fatigue. In the remaining study, an accelerometer was used to measure daily activities, sleeping time and their relationships with fatigue in a more quantifiable manner. Adolescents with IBD are significantly more fatigued than healthy controls. In addition to active disease, increased anxiety or depression and disturbed family relationships were frequently reported predictors of fatigue. Quantitative measurement of physical activity in patients with Crohn's disease showed a reduction in the number of steps per day, and patients with ulcerative colitis had a shorter duration of physical activity during the day.
conclusionFatigue in pediatric IBD is related to a combination of biological, functional and behavioral factors, which should all be taken into account when managing fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.