Evidence map›Paper›PMID 30774271›Full record

ReviewWorld journal of gastroenterology2019

Functional gastrointestinal disorders and gut-brain axis: What does the future hold?

Kashif Mukhtar, Hasham Nawaz, Shahab Abid

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in World journal of gastroenterology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
67citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

67 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  10. What goes down may come up: regurgitative behaviors and their underlying gut-brain axes-insights from genetic models and related pathologies.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
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7 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kashif MukhtarCentre of Excellence in Women and Child Health, Aga Khan University, Karachi, Sindh 74800, Pakistan.
Hasham NawazDepartment of Medicine, Section of Gastroenterology, Aga Khan University, Karachi, Sindh 74800, Pakistan.
Shahab AbidDepartment of Medicine, Section of Gastroenterology, Aga Khan University, Karachi, Sindh 74800, Pakistan. shahab.abid@aku.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite their high prevalence, lack of understanding of the exact pathophysiology of the functional gastrointestinal disorders has restricted us to symptomatic diagnostic tools and therapies. Complex mechanisms underlying the disturbances in the bidirectional communication between the gastrointestinal tract and the brain have a vital role in the pathogenesis and are key to our understanding of the disease phenomenon. Although we have come a long way in our understanding of these complex disorders with the help of studies on animals especially rodents, there need to be more studies in humans, especially to identify the therapeutic targets. This review study looks at the anatomical features of the gut-brain axis in order to discuss the different factors and underlying molecular mechanisms that may have a role in the pathogenesis of functional gastrointestinal disorders. These molecules and their receptors can be targeted in future for further studies and possible therapeutic interventions. The article also discusses the potential role of artificial intelligence and machine learning and its possible role in our understanding of these scientifically challenging disorders.

Indexed as

AnimalsAnti-Bacterial AgentsDiagnosis, Computer-AssistedDysbiosisGastrointestinal DiseasesGastrointestinal MicrobiomeGastrointestinal TractHumansHypothalamo-Hypophyseal SystemMachine LearningNeural PathwaysNeuroimagingProbioticsVagus NerveAnti-Bacterial AgentsArtificial intelligenceFunctional gastrointestinal disordersGut-brain axisIdiopathic bowel syndromeMachine learningMicrobiome-gut-brain axis

Identifiers

PMID30774271
PMCPMC6371005

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.