Evidence map›Paper›PMID 30774065›Full record

ArticlePublic health nutrition2019

Protein intake and the risk of premenstrual syndrome.

Serena C Houghton, JoAnn E Manson, Brian W Whitcomb, Susan E Hankinson, Lisa M Troy, Carol Bigelow, Elizabeth R Bertone-Johnson

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Public health nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Serena C Houghton1Department of Biostatistics and Epidemiology,University of Massachusetts,715 North Pleasant Street,Arnold House 412,Amherst,MA01003,USA.ORCID 0000-0001-8833-9065
JoAnn E Manson2Channing Division of Network Medicine,Department of Medicine,Brigham and Women's Hospital and Harvard Medical School,Boston,MA,USA.
Brian W Whitcomb1Department of Biostatistics and Epidemiology,University of Massachusetts,715 North Pleasant Street,Arnold House 412,Amherst,MA01003,USA.
Susan E Hankinson1Department of Biostatistics and Epidemiology,University of Massachusetts,715 North Pleasant Street,Arnold House 412,Amherst,MA01003,USA.
Lisa M Troy5Department of Nutrition,University of Massachusetts,Amherst,MA,USA.
Carol Bigelow1Department of Biostatistics and Epidemiology,University of Massachusetts,715 North Pleasant Street,Arnold House 412,Amherst,MA01003,USA.
Elizabeth R Bertone-Johnson1Department of Biostatistics and Epidemiology,University of Massachusetts,715 North Pleasant Street,Arnold House 412,Amherst,MA01003,USA.
University of Massachusetts Amherst · USBrigham and Women's Hospital · US

Funding

Life Course Cancer Epidemiology Cohort in WomenU01CA176726 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 2018 to 2025
$22.4M
Life Course Cancer Epidemiology Cohort in WomenUM1CA176726 · NCI · HARVARD SCHOOL OF PUBLIC HEALTH · PI WILLETT, WALTER C. · 2013 to 2017
$15.7M
Epidemiology of premenstrual syndrome and premenstrual dysphoric disorderK01MH076274 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI BERTONE-JOHNSON, ELIZABETH R · 2007 to 2011
$848k
NCI NIH HHS U01 CA176726NCI NIH HHS UM1 CA176726NIMH NIH HHS K01 MH076274
6 · The paper itself

Abstract

objectiveTo examine the relationship between protein intake and the risk of incident premenstrual syndrome (PMS).

designNested case-control study. FFQ were completed every 4 years during follow-up. Our main analysis assessed protein intake 2-4 years before PMS diagnosis (for cases) or reference year (for controls). Baseline (1991) protein intake was also assessed.

settingNurses' Health Study II (NHS2), a large prospective cohort study of registered female nurses in the USA.ParticipantsParticipants were premenopausal women between the ages of 27 and 44 years (mean: 34 years), without diagnosis of PMS at baseline, without a history of cancer, endometriosis, infertility, irregular menstrual cycles or hysterectomy. Incident cases of PMS (n 1234) were identified by self-reported diagnosis during 14 years of follow-up and validated by questionnaire. Controls (n 2426) were women who did not report a diagnosis of PMS during follow-up and confirmed experiencing minimal premenstrual symptoms.

resultsIn logistic regression models adjusting for smoking, BMI, B-vitamins and other factors, total protein intake was not associated with PMS development. For example, the OR for women with the highest intake of total protein 2-4 years before their reference year (median: 103·6 g/d) v. those with the lowest (median: 66·6 g/d) was 0·94 (95 % CI 0·70, 1·27). Additionally, intakes of specific protein sources and amino acids were not associated with PMS. Furthermore, results substituting carbohydrates and fats for protein were also null.

conclusionsOverall, protein consumption was not associated with risk of developing PMS.

Indexed as

AdultCase-Control StudiesDietDietary ProteinsDiet SurveysEatingFemaleFollow-Up StudiesHumansIncidenceLogistic ModelsNursesPremenstrual SyndromeRisk FactorsUnited StatesDietary ProteinsDietEpidemiologyNurses’ Health Study IIPremenstrual syndromeProtein

Identifiers

PMID30774065
PMCPMC6554041
OpenAlexW2916501926

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.