Evidence map›Paper›PMID 30773828›Full record

ArticleJournal of thrombosis and haemostasis : JTH2019

Factor XIII topology: organization of B subunits and changes with activation studied with single-molecule atomic force microscopy.

Anna D Protopopova, Andrea Ramirez, Dmitry V Klinov, Rustem I Litvinov, John W Weisel

Open access · bronzeAbstract read
In one paragraph

Article in Journal of thrombosis and haemostasis : JTH, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Fibrin as a Versatile Fibrous Biopolymer.Sub-cellular biochemistry · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Anna D ProtopopovaDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Andrea RamirezDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
Dmitry V KlinovFederal Research and Clinical Center of Physical-Chemical Medicine, Moscow, Russian Federation.
Rustem I LitvinovDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
John W WeiselDepartment of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.
University of Pennsylvania · USFederal Research and Clinical Center of Physical-Chemical Medicine named after Y.M. Lopukhin · RUKazan Federal University · RUThe University of Texas at El Paso · US

Funding

Multiscale modeling and empirical study of a mechanism limiting blood clot growthU01HL116330 · NHLBI · UNIVERSITY OF NOTRE DAME · PI ALBER, MARK · 2014 to 2018
$3.5M
Experiment-based multi-scale modeling of the tensile and compressive deformations of fibrinR01HL135254 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PUROHIT, PRASHANT KISHORE · 2017 to 2020
$1.6M
NHLBI NIH HHS R01 HL135254NHLBI NIH HHS U01 HL116330
6 · The paper itself

Abstract

Essentials Factor XIII is a heterotetramer with 2 catalytic A subunits and 2 non-catalytic B subunits. Structure of active and inactive factor XIII was studied with atomic force microscopy. Inactive factor XIII is made of an A

Indexed as

Microscopy, Atomic ForceBlood Coagulation TestsCalciumCatalysisCatalytic DomainFactor XIIIFactor XIIIaFibrinHumansProtein DomainsProtein MultimerizationRecombinant ProteinsThrombinTransglutaminasesCalciumFactor XIIIFactor XIIIaFibrinRecombinant ProteinsThrombinTransglutaminasesatomic force microscopybloodblood coagulation factorfactor XIIItransglutaminases

Identifiers

PMID30773828
PMCPMC6917434
OpenAlexW2915603962

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.