Evidence map›Paper›PMID 30773823›Full record

ArticleInternational wound journal2019

Inflammatory biomarkers, vascular procedures of lower limbs, and wound healing.

Paolo Sapienza, Andrea Mingoli, Valeria Borrelli, Gioia Brachini, Daniele Biacchi, Antonio V Sterpetti, Raffaele Grande, Raffaele Serra, Elvira Tartaglia

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International wound journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 33 citations in OpenAlex.

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  16. The Role of Circulating Biomarkers in Peripheral Arterial Disease.International journal of molecular sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Paolo SapienzaDepartment of General and Plastic Surgery "Pietro Valdoni", "Sapienza" University of Rome, Rome, Italy.ORCID https://orcid.org/0000-0002-0198-7930
Andrea MingoliEmergency Department, "Sapienza" University of Rome, Rome, Italy.
Valeria BorrelliDepartment of Diagnostic Medicine, "Sapienza", University of Rome, Rome, Italy.
Gioia BrachiniDepartment of General and Plastic Surgery "Pietro Valdoni", "Sapienza" University of Rome, Rome, Italy.
Daniele BiacchiDepartment of General and Plastic Surgery "Pietro Valdoni", "Sapienza" University of Rome, Rome, Italy.
Antonio V SterpettiDepartment of General and Plastic Surgery "Pietro Valdoni", "Sapienza" University of Rome, Rome, Italy.
Raffaele GrandeDepartment of General and Plastic Surgery "Pietro Valdoni", "Sapienza" University of Rome, Rome, Italy.
Raffaele SerraDepartment of Medical and Surgical Sciences, University "Magna Graecia", Catanzaro, Catanzaro, Italy.
Elvira TartagliaDepartment of Vascular and Endovascular Surgery, Centre Hospitalier Sud Francilien, Paris, France.
Sapienza University of Rome · ITCentre Hospitalier Sud Francilien · FRMagna Graecia University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abnormal, persistent inflammation after bypass surgery could prevent healing of an ischaemic foot lesion. In 37 patients with peripheral arterial disease (PAD) (Rutherford Grade III Category 5) who underwent infrapopliteal vein graft and midfoot amputation, plasma levels of fibrinogen, C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) were determined preoperatively and during the follow up. Nine patients without clinical and Doppler evidence of arterial disease, who underwent post-traumatic midfoot primary amputation, were included in the experiment group, and 15 age-matched healthy volunteers served as control. In patients who had midfoot amputation for trauma, all wounds healed. Seven (19%) wounds in patients with an occluded graft healed, and five (13%) required major amputation because of a non-healing wound. Time required for complete healing of the lesion was similar between trauma and PAD patients (8 ± 2 months vs 11 ± 6, respectively, P = NS). Univariate analysis demonstrated that, in PAD patients, the postoperative high levels of TNF-α, IL-6, and MMP-2 and -9 were predictive for wound healing failure at 3, 6, and 9 months (P < 0.05), respectively. Furthermore, the subgroup of patients who experienced occlusion of the vein graft during follow up had a significant increase of MMP-2, -9, IL-6, and TNF-α at 3, 6, and 9 months (P < 0.05), respectively. Monitoring inflammatory markers allows the determination of patients at risk of healing failure of midfoot amputation after distal revascularisation and might predict the fate of the vein graft.

Indexed as

AgedBiomarkersFemaleFollow-Up StudiesFootHumansInflammationMaleMiddle AgedPeripheral Arterial DiseaseRetrospective StudiesTreatment OutcomeVascular Surgical ProceduresVeinsWound HealingBiomarkersbypasscytokinesischaemiametalloproteinasestrauma

Identifiers

PMID30773823
PMCPMC7948871
OpenAlexW2915153477

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.