ArticleVeterinary ophthalmology2019
Quantitative, noninvasive assessment of intra- and extraocular perfusion by contrast-enhanced ultrasonography and its clinical applicability in healthy dogs.
Article in Veterinary ophthalmology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 7 citations in OpenAlex.
- Contrast-enhanced ultrasound characteristics in orbital cavernous venous malformation.Experimental and therapeutic medicine · 2025Article
- Ultrasound-Based Technologies for the Evaluation of Testicles in the Dog: Keystones and Breakthroughs.Veterinary sciences · 2023Review
- Ocular Ultrasonography in Healthy Calves with Different Transducers.Animals : an open access journal from MDPI · 2023Article
- Clinical utility, dose determination, and safety of ocular contrast-enhanced ultrasonography in horses: A pilot study.Veterinary ophthalmology · 2020Article
- Quantitative, noninvasive assessment of intra- and extraocular perfusion by contrast-enhanced ultrasonography and its clinical applicability in healthy dogs.Veterinary ophthalmology · 2019Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess quantitative perfusion of intra- and extraocular regions of interest (ROIs) in conscious, healthy dogs utilizing contrast-enhanced ultrasonography (CEUS); to compare varying enhancement with the first and second bolus injection and in the right and left eye; and to determine the most appropriate examination time. PROCEDURES: Gray scale ultrasonography and contrast harmonic imaging using sulfur hexafluoride were performed randomly assigned in both eyes in 10 university-owned beagles. Perfusion parameters including slope time, time to peak (TTP), peak intensity (PI), and area under the curve (AUC) were measured at individually drawn ROIs (retrobulbar cone = ROI 1, choroid-retina complex = ROI 2, medial = ROI 3, and lateral anterior uvea = ROI 4).
resultsTime-intensity curve parameters revealed no significant differences in eyes examined by the first or second bolus injection (P > 0.05) or in the right or left eye (P > 0.05). Pooled data from all eyes were analyzed. Peak intensity of ROI 2 was significantly higher compared to all other ROIs (P < 0.001). Area under the curve at ROI 2 was significantly higher compared to all other ROIs (P < 0.05), and AUC at ROI 1 was significantly higher than at ROI 4 (P < 0.05). No significant differences in TTP were observed between different ROIs (P > 0.05). Ratios relative to different ROI sizes showed fastest enhancement in the retrobulbar cone and most intense perfusion in the anterior uveal regions. The first minute after contrast injection provided the highest diagnostic value.
conclusionQuantitative perfusion in nondiseased canine eyes revealed consistent parameters. Application of standardized CEUS protocols may be a promising diagnostic tool to differentiate ocular lesions.
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