Evidence map›Paper›PMID 30773506›Full record

ArticleThe Journal of reproduction and development2019

The phenotype of a pig with monosomy X resembling Turner syndrome symptoms: a case report.

Kazuhiro Umeyama, Kazuaki Nakano, Hitomi Matsunari, Takeshi Yamada, Koki Hasegawa, Kun Tang, Yuki Tokuyama, Masahito Watanabe, Masaki Nagaya, Hiroshi Nagashima

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of reproduction and development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Kazuhiro UmeyamaMeiji University International Institute for Bio-Resource Research, Kanagawa 214-8571, Japan.
Kazuaki NakanoLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Hitomi MatsunariMeiji University International Institute for Bio-Resource Research, Kanagawa 214-8571, Japan.
Takeshi YamadaLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Koki HasegawaLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Kun TangLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Yuki TokuyamaLaboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, Kanagawa 214-8571, Japan.
Masahito WatanabeMeiji University International Institute for Bio-Resource Research, Kanagawa 214-8571, Japan.
Masaki NagayaMeiji University International Institute for Bio-Resource Research, Kanagawa 214-8571, Japan.
Hiroshi NagashimaMeiji University International Institute for Bio-Resource Research, Kanagawa 214-8571, Japan.
Meiji University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The partial or complete loss of one X chromosome in humans causes Turner syndrome (TS), which is accompanied by a range of physical and reproductive pathologies. This article reports similarities between the phenotype of a pig with monosomy X and the symptoms of TS in humans. Born as the offspring of a male pig carrying a mutation in an X-chromosomal gene, ornithine transcarbamylase (OTC), the female pig (37,XO) was raised to the age of 36 months. This X-monosomic pig presented with abnormal physical characteristics including short stature, micrognathia, and skeletal abnormalities in the limbs. Furthermore, the female did not exhibit an estrous cycle, even after reaching the age of sexual maturity, and showed no ovarian endocrine activity except for an irregular increase in blood 17β-estradiol levels, which was seemingly attributable to sporadic follicular development. An autopsy at 36 months revealed an undeveloped reproductive tract with ovaries that lacked follicles. These data demonstrated that the growth processes and anatomical and physiological characteristics of an X-monosomic pig closely resembled those of a human with TS.

Indexed as

X ChromosomeAnimalsAutopsyDisease Models, AnimalFemaleGenes, X-LinkedKaryotypingMaleMonosomyMutationOrnithine CarbamoyltransferaseOvarian FolliclePhenotypeSwineTomography, X-Ray ComputedTurner SyndromeOrnithine CarbamoyltransferaseMonosomy XPigTurner syndrome

Identifiers

PMID30773506
PMCPMC6584175
OpenAlexW2911996878

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.