ArticleCell chemical biology2019
Identification of a Molecular Latch that Regulates Staphylococcal Virulence.
Article in Cell chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- A secreted AIP-Like peptide fromVirulence · 2026Article
- Loss of Fsr quorum sensing promotes biofilm formation and worsens outcomes in enterococcal infective endocarditis.Nature communications · 2026Article
- Bacterial quorum-sensing systems in cell-cell communication.FEMS microbiology reviews · 2026Review
- Utilization of probiotics against virulence factors of Staphylococcus aureus in bovine mastitis.Antonie van Leeuwenhoek · 2025Review
- Molecular Mechanisms of Virulence Regulation inAccounts of chemical research · 2025Article
- AACS synthetic biology · 2025Article
- Review
- Quorum-sensing, intra- and inter-species competition in the staphylococci.Microbiology (Reading, England) · 2023Review
- Chemical and biomolecular insights into theIsrael journal of chemistry · 2023Article
- Integrative Multiomics Analysis of the Heat Stress Response ofBiomolecules · 2023Article
- Computational tools for exploring peptide-membrane interactions in gram-positive bacteria.Computational and structural biotechnology journal · 2023Review
- Reconstitution of theProceedings of the National Academy of Sciences of the United States of America · 2022Article
- Anti-Quorum Sensing Activities of Gliptins againstBiomedicines · 2022Article
- Evolution of two-component quorum sensing systems.Access microbiology · 2022Article
- Two-Component Systems ofGenes · 2021Review
- Discovery of quorum quenchers targeting the membrane-embedded sensor domain of theChemical communications (Cambridge, England) · 2020Article
- Timing Is Everything: Impact of Naturally OccurringJournal of bacteriology · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Virulence induction in the Staphylococcus aureus is under the control of a quorum sensing (QS) circuit encoded by the accessory gene regulator (agr) locus. Allelic variation within agr produces four QS specificity groups, each producing a unique secreted autoinducer peptide (AIP) and receptor histidine kinase (RHK), AgrC. Cognate AIP-AgrC interactions activate virulence through a two-component signaling cascade, whereas non-cognate pairs are generally inhibitory. Here we pinpoint a key hydrogen-bonding interaction within AgrC that acts as a switch to convert helical motions propagating from the receptor sensor domain into changes in inter-domain association within the kinase module. AgrC mutants lacking this interaction are constitutively active in vitro and in vivo, the latter leading to a pronounced attenuation of S. aureus biofilm formation. Thus, our work sheds light on the regulation of this biomedically important RHK.
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Registered trials
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