Evidence map›Paper›PMID 30773462›Full record

ArticleCell metabolism2019

Calcium Signaling Controls Pathogenic Th17 Cell-Mediated Inflammation by Regulating Mitochondrial Function.

Ulrike Kaufmann, Sascha Kahlfuss, Jun Yang, Elitza Ivanova, Sergei B Koralov, Stefan Feske

Open access · bronzeAbstract read
In one paragraph

Article in Cell metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers.

0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

101 citing papers in PubMed, 146 citations in OpenAlex.

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  16. Epithelial pyroptosis-induced TREM1Cell death discovery · 2025
    Article
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  20. Review

41 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

  • Commented on by
    T2019
5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Ulrike KaufmannDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Sascha KahlfussDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Jun YangDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Elitza IvanovaDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Sergei B KoralovDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Stefan FeskeDepartment of Pathology, New York University School of Medicine, New York, NY 10016, USA. Electronic address: feskes01@nyumc.org.
New York University · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1M
CRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6M
Microbial triggers and molecular mechanisms of Th17 mediated airway inflammation-Resubmission-1R01HL125816 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI KORALOV, SERGEI BORISOVICH · 2015 to 2019
$3.3M
Regulation of Follicular T cell Responses in the Lung by Ion ChannelsR01AI130143 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2017 to 2021
$2.4M
Regulation of encephalitogenic T cells by CRAC channelsR01AI137004 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2018 to 2022
$2.4M
Identifying Novel Ion Channels Regulating T cell FunctionR21AI125997 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2016 to 2017
$466k
Acquisition of a Seahorse XFS10OD016304 · OD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI RAMASAMY, RAVICHANDRAN · 2013 to 2013
$126k
NCI NIH HHS P30 CA016087NHLBI NIH HHS R01 HL125816NIAID NIH HHS R01 AI097302NIAID NIH HHS R01 AI130143NIAID NIH HHS R01 AI137004NIAID NIH HHS R21 AI125997NIH HHS S10 OD016304
6 · The paper itself

Abstract

Pathogenic Th17 cells play important roles in many autoimmune and inflammatory diseases. Their function depends on T cell receptor (TCR) signaling and cytokines that activate signal transducer and activator of transcription 3 (STAT3). TCR engagement activates stromal interaction molecule 1 (STIM1) and calcium (Ca

Indexed as

Calcium SignalingAnimalsCalciumInflammationMiceMice, TransgenicMitochondriaOxidative PhosphorylationOxidative StressReactive Oxygen SpeciesReceptors, Antigen, T-CellSTAT3 Transcription FactorStromal Interaction Molecule 1Th17 CellsTranscriptomeCalciumReactive Oxygen SpeciesReceptors, Antigen, T-CellStat3 protein, mouseSTAT3 Transcription FactorStim1 protein, mouseStromal Interaction Molecule 1airway inflammationantioxidantCa2+calciumcolitiselectron transport chainETCIL-17metabolismmitochondriaoxidative phosphorylationOXPHOSpathogenic T helper 17 cellsreactive oxygen speciesROSSOCESTAT3STIM1store-operated calcium entryTh17

Identifiers

PMID30773462
PMCPMC6506368
OpenAlexW2914840597

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.